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AB SCIEX Triple Quad 6500+ LC-MS/MS  ultra-sensitive, high-throughput triple quadrupole mass spectrometer for pharmaceutical, food safety, environmental, and clinical targeted quantitation.

Key Features:

  • Next-Generation Quantitation Power: Builds on the legacy of the SCIEX 6500, delivering sub-femtogram sensitivity for the most demanding applications.

  • OptiFlow® Turbo V Source: Supports both microflow and standard flow LC seamlessly, maximizing flexibility and sensitivity.

  • SelexION® Differential Mobility Technology (DMS): Optional add-on for increased selectivity by separating isobaric compounds before MS analysis.

  • Fast Polarity Switching: <5 ms for efficient acquisition in mixed-ion workflows.

  • High-Speed Acquisition: Up to 5,000 MRM transitions/sec with ultra-fast cycle times for multiplexed assays.

  • Increased Dynamic Range: Wide linear range enables quantification of analytes from trace levels to high abundance.

  • Robust Design: Optimized ion optics and collision cell (LINAC® technology) reduce crosstalk and maximize throughput.

  • Data Integrity: Supports 21 CFR Part 11 compliance, making it suitable for regulated labs.

  • Analyst® and SCIEX OS Software: Advanced data acquisition, processing, and compliance-ready reporting.


Applications:

  • Pharmaceutical & Biopharma R&D: Pharmacokinetics, bioequivalence, metabolite identification, impurity profiling.

  • Food Safety Testing: Residues of pesticides, veterinary drugs, and contaminants at ultra-trace levels.

  • Environmental Monitoring: Quantitation of pollutants, persistent organic contaminants, and emerging trace chemicals.

  • Clinical & Forensic Research: Toxicology, therapeutic drug monitoring, forensic drug screening.

  • Biological Studies: Targeted metabolomics, lipidomics, and proteomics with microflow LC compatibility.


Specifications (Table):

Parameter Specification
MS Type Triple Quadrupole LC-MS/MS
Mass Range m/z 5 – 2,000
Resolution Unit resolution (0.7 Da FWHM)
Polarity Switching <5 ms
Dynamic Range >6 orders of magnitude
MRM Transitions Up to 5,000 transitions/sec
Acquisition Modes MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan
Ionization Sources Turbo V™, OptiFlow® Turbo V, DuoSpray®, APCI
SelexION® Technology Optional – Differential Ion Mobility for improved selectivity
Collision Cell LINAC® collision cell technology
Vacuum System Dual turbomolecular pumps
Software Analyst® and SCIEX OS
Compliance 21 CFR Part 11, GLP/GMP ready


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