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AB Sciex TripleTOF 5600+ Mass Spectrometer high-resolution quadrupole time-of-flight system for proteomics, metabolomics, pharmaceutical research, food safety, and environmental testing.

Key Features:

  • High-Resolution Accurate Mass (HRAM): Combines quadrupole selectivity with TOF resolution for both qualitative and quantitative workflows.

  • Ultra-Fast Acquisition Speed: Capable of >100 spectra/sec for compatibility with UHPLC separations.

  • High Sensitivity: fg-level detection enables analysis of low-abundance compounds in complex matrices.

  • Dynamic Range: >5 orders of magnitude for simultaneous quantitation of trace and major analytes.

  • SWATH® Acquisition Technology: Enables comprehensive data-independent acquisition (DIA) for proteomics and metabolomics.

  • Powerful Ion Optics: Optimized for high ion transmission and reduced background noise.

  • Dual Ion Sources: Supports ESI and APCI for wide application coverage.

  • Flexible Acquisition Modes: Information-dependent acquisition (IDA), MS/MSALL, and targeted MS/MS for discovery and verification workflows.

  • Robust Hardware Design: Engineered for long-term stability and reproducibility in high-throughput labs.

  • Software Ecosystem: SCIEX OS and Analyst® TF software for acquisition, data processing, and regulatory compliance.


Applications:

  • Proteomics: Comprehensive protein identification, biomarker discovery, SWATH-based quantitation.

  • Metabolomics & Lipidomics: Untargeted and targeted profiling of metabolites and lipids.

  • Pharmaceutical Research: Drug metabolism (DMPK), pharmacokinetics (PK/PD), impurity identification, metabolite profiling.

  • Clinical & Translational Research: Biomarker discovery, quantitative verification studies.

  • Food & Environmental Testing: Screening for contaminants, toxins, pesticides, and emerging pollutants.


Specifications (Table):

Parameter Specification
System Configuration AB Sciex TripleTOF 5600+ Mass Spectrometer
MS Type Hybrid Quadrupole-Time-of-Flight (Q-TOF)
Mass Range m/z ~50 – 40,000 (depending on mode)
Resolution >30,000 FWHM
Mass Accuracy <1 ppm with internal calibration
Dynamic Range >5 orders of magnitude
Acquisition Speed >100 spectra/sec
Ionization Modes ESI, APCI
Polarity Switching <50 ms
Acquisition Modes Full Scan MS, IDA, SWATH DIA, MS/MSALL, Product Ion
LOD/LOQ Sensitivity fg–pg level detection (compound dependent)
Collision Cell Q2 linear accelerator collision cell
Vacuum System Turbo molecular pumps with differential pumping
Interface Turbo V™ Source, optional DuoSpray®
Software SCIEX OS, Analyst® TF
Compliance 21 CFR Part 11, GLP/GMP ready


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