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Key Features:
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Combines the Agilent 1290 Infinity II UHPLC for ultra-high performance separations with the 6546 Q-TOF LC/MS for accurate mass, high-resolution detection.
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High-resolution accurate mass (HRAM) capability ensures confident compound identification and quantification.
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Enhanced mass accuracy and stability with Agilent’s True Peak positioning and reference mass correction.
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Wide dynamic range with fast acquisition rates, ideal for untargeted and targeted workflows.
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Advanced dual Agilent Jet Stream (AJS) technology for efficient ionization and maximum sensitivity.
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Seamless integration with MassHunter software for qualitative and quantitative data analysis.
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Suited for both discovery research and regulated applications requiring data integrity.
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Applications:
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Proteomics & Metabolomics: Biomarker discovery, protein and metabolite profiling, and systems biology.
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Pharmaceutical Development: Impurity analysis, drug discovery, metabolite identification, and PK studies.
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Environmental Testing: Screening of contaminants, pollutants, and emerging chemical threats.
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Food Safety & Authenticity: Detection of adulterants, residues, and nutritional profiling.
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Omics Research & Academia: Comprehensive small molecule and large molecule characterization.
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Specifications:
| Specification | Detail |
|---|---|
| LC/MS Platform | Agilent 1290 Infinity II UHPLC with 6546 Q-TOF LC/MS |
| MS System Type | Quadrupole Time-of-Flight (Q-TOF), High-Resolution Accurate Mass (HRAM) |
| Mass Range | m/z 20–40,000 (extended range for biomolecules) |
| Resolution | >60,000 FWHM |
| Ionization Modes | ESI, APCI, dual AJS (Agilent Jet Stream) |
| Autosampler | 1290 Infinity II autosampler |
| Acquisition Modes | MS, MS/MS (data-dependent and data-independent, including SWATH/All-Ions) |
| Dynamic Range | >5 orders of magnitude |
| Mass Accuracy | <1 ppm with reference mass correction |
| Vacuum System | High-capacity turbomolecular pump system |
| Interface | Dual AJS ESI source, interchangeable ion sources |
| Software | Agilent MassHunter (Qualitative, Quantitative, Profinder, and VistaFlux) |
| Compliance | 21 CFR Part 11 compatible |