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Agilent 6490 Triple Quadrupole LC-MS/MS with 1260 Infinity II DAD UHPLC high-sensitivity quantitative LC-MS system for pharmaceutical, food safety, environmental, clinical, and metabolomics applications.
  • Agilent 6490 Triple Quadrupole LC-MS/MS with 1260 Infinity II DAD UHPLC high-sensitivity quantitative LC-MS system for pharmaceutical, food safety, environmental, clinical, and metabolomics applications.
  • Agilent 6490 Triple Quadrupole LC-MS/MS with 1260 Infinity II DAD UHPLC high-sensitivity quantitative LC-MS system for pharmaceutical, food safety, environmental, clinical, and metabolomics applications.
Agilent 6490 Triple Quadrupole LC-MS/MS System with 1260 Infinity II DAD Front-End LC-MS System
$0.00

Key Features:

  • High Sensitivity Quantitation: Sub-femtogram detection limits with exceptional reproducibility for complex samples.

  • iFunnel Technology: Efficient ion funnel optics enhance ion transmission and boost sensitivity.

  • 1260 Infinity II DAD UHPLC Front-End: Integrates a diode array detector with precise UHPLC performance, enabling optical and mass-based detection workflows.

  • Wide Dynamic Range: >5–6 orders of magnitude dynamic range for reliable quantitation across varying concentrations.

  • Fast Polarity Switching: <20 ms polarity change for efficient positive/negative ion detection in a single run.

  • High MRM Throughput: Capable of >500 MRM transitions/sec to match narrow UHPLC peaks.

  • Enhanced Collision Cell: LCID (linear collision cell with axial acceleration) for robust, high-quality fragmentation.

  • Multiple Ionization Sources: Compatible with Agilent Jet Stream ESI, APCI, and multimode sources.

  • Streamlined Maintenance: Modular design with user-friendly serviceability to minimize downtime.

  • Regulatory-Ready Workflows: Full 21 CFR Part 11 compliance with audit trails and secure reporting in GMP/GLP environments.

  • MassHunter Software: Simplifies method development, targeted quantitation, and compliance documentation.

Applications:

  • Pharmaceutical Development: Pharmacokinetics (PK), DMPK, impurity profiling, clinical bioanalysis.

  • Biopharmaceuticals: Targeted protein/peptide quantitation, stability studies, process monitoring.

  • Food Safety & Quality: Quantitative analysis of pesticide residues, mycotoxins, contaminants, and veterinary drugs.

  • Environmental Analysis: Trace-level detection of emerging pollutants, pharmaceuticals, and industrial contaminants.

  • Clinical & Forensic Toxicology: Drug testing, biomarker quantitation, and forensic screening workflows.

  • Metabolomics & Lipidomics: Targeted metabolite and lipid quantitation in biological systems.

  • Routine Regulated Labs: High-throughput quantitation with validated, compliance-ready methods.

Specifications (Table):

Parameter Specification
System Configuration Agilent 6490 Triple Quadrupole LC-MS/MS with Agilent 1260 Infinity II UHPLC (with Diode Array Detector)
MS Type Triple Quadrupole LC/MS (LC-MS/MS)
Model 6490
Mass Range m/z 10 – 3,000
Resolution Unit mass resolution (0.7 Da FWHM)
Dynamic Range >5–6 orders of magnitude
Mass Accuracy High reproducibility for targeted quantitation
Ionization Modes Jet Stream ESI, APCI, multimode
Polarity Switching <20 ms
Acquisition Modes MRM, dynamic MRM (dMRM), SIM
MRM Transition Speed >500 transitions/sec
Sensitivity (LOQ) Sub-femtogram detection (compound dependent)
Collision Cell LCID with axial acceleration
Vacuum System Turbo molecular pumps
UHPLC System Agilent 1260 Infinity II with DAD (Diode Array Detector), pressure up to 600 bar
Interface Orthogonal ESI with iFunnel technology
Autosampler Integrated 1260 Infinity II autosampler
Software Agilent MassHunter (method development, quantitation, reporting)
Compliance 21 CFR Part 11, GLP/GMP support



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