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Key Features:
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Integrated LC-MS Solution: Combines Bruker maXis Q-TOF with Elute UHPLC, designed as a complete, optimized LC-MS/MS workflow.
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High-Resolution MS: Achieves >60,000 FWHM with sub-ppm mass accuracy for precise molecular identification.
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Wide Dynamic Range: Greater than 5 orders of magnitude, suitable for both trace-level and high-abundance compounds.
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Fast UHPLC Separation: Elute UHPLC supports pressures up to 1300 bar and sub-2 µm particle columns for sharp peak resolution.
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High-Speed Acquisition: Up to 20 Hz scan rate for compatibility with fast UHPLC gradients.
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Flexible Ionization Options: ESI, nanoESI, APCI, APPI, and MALDI sources.
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Advanced Fragmentation: Collision-induced dissociation (CID) with optional ETD for comprehensive molecular characterization.
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Regulatory Ready: Supports 21 CFR Part 11 compliance for pharmaceutical and GxP workflows.
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Software Ecosystem: Integrated with Bruker Compass DataAnalysis, MetaboScape, ProteinScape, and BioPharma Compass for end-to-end data interpretation.
Applications:
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Proteomics & Biopharma: Protein and peptide characterization, mAb analysis, glycosylation profiling, and PTM mapping.
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Metabolomics & Lipidomics: Untargeted and targeted profiling with high resolution and accuracy.
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Pharmaceutical R&D: Impurity profiling, drug metabolism, pharmacokinetics (DMPK), and small molecule quantitation.
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Food & Environmental Testing: Detection of contaminants, toxins, and pesticide residues.
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Clinical & Biomarker Discovery: Sensitive analysis for translational and personalized medicine research.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Quadrupole Time-of-Flight (QTOF) LC-MS/MS |
| Mass Range | m/z 50 – 20,000 |
| Resolution | >60,000 FWHM |
| Mass Accuracy | <1 ppm (internal calibration) |
| Scan Speed | Up to 20 Hz |
| UHPLC System | Bruker Elute UHPLC (up to 1300 bar, sub-2 µm particle compatibility) |
| Ionization Sources | ESI, nanoESI, APCI, APPI, MALDI |
| Fragmentation Modes | CID, optional ETD |
| Dynamic Range | >5 orders of magnitude |
| Software | Compass DataAnalysis, MetaboScape, ProteinScape, BioPharma Compass |
| Compliance | 21 CFR Part 11 ready |