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Key Features:
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High-Resolution QTOF: Provides mass resolution >60,000 FWHM for confident molecular identification.
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Accurate Mass Measurement: Sub-ppm mass accuracy with internal calibration for reliable formula determination.
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Fast Acquisition Speed: Suitable for UHPLC applications with scan rates up to 20 Hz, ideal for fast chromatographic separations.
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Broad Dynamic Range: Linear dynamic range over 5 orders of magnitude for quantifying trace and abundant compounds simultaneously.
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Dual Ion Funnel Technology: Enhances sensitivity and transmission efficiency.
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Versatile Ionization Sources: Compatible with ESI, nanoESI, APCI, APPI, and MALDI.
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MS/MS Fragmentation: Provides high-quality spectra with CID and optional ETD for structural elucidation.
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Software Integration: Works with Bruker Compass DataAnalysis, MetaboScape, ProteinScape, and BioPharma Compass.
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Flexibility for Omics: Optimized for proteomics, metabolomics, lipidomics, and glycomics workflows.
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Regulatory Support: 21 CFR Part 11 compliance-ready for GxP environments.
Applications:
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Proteomics: High-resolution peptide and protein identification, top-down/bottom-up workflows.
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Metabolomics & Lipidomics: Comprehensive untargeted and targeted metabolite profiling.
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Pharmaceutical Research: Drug discovery, impurity profiling, and biopharmaceutical characterization.
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Glycomics & Biotherapeutics: Characterization of glycans, monoclonal antibodies, and complex biologics.
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Clinical & Translational Research: Biomarker discovery and validation.
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Environmental & Food Analysis: Detection of contaminants, pesticides, and trace pollutants.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Quadrupole Time-of-Flight (QTOF) LC-MS |
| Mass Range | m/z 50 – 20,000 |
| Resolution | >60,000 FWHM |
| Mass Accuracy | <1 ppm with internal calibration |
| Scan Speed | Up to 20 Hz |
| Ionization Sources | ESI, nanoESI, APCI, APPI, MALDI |
| Fragmentation Modes | CID, optional ETD |
| Acquisition Modes | Full Scan, MS/MS, Data-Dependent Acquisition (DDA), Data-Independent Acquisition (DIA) |
| Dynamic Range | >5 orders of magnitude |
| Ion Optics | Dual Ion Funnel technology |
| Software | Compass DataAnalysis, ProteinScape, MetaboScape, BioPharma Compass |
| Compliance | 21 CFR Part 11 ready |