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Key Features:
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High-Resolution QTOF MS: Bruker maXis delivers >60,000 FWHM resolution with sub-ppm mass accuracy for advanced research.
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Fast UHPLC Separation: Integrated with Agilent 1290 Infinity II UHPLC for ultra-high pressure liquid chromatography (up to 1300 bar) ensuring sharp peaks and high throughput.
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Accurate Quantification: Broad dynamic range (>5 orders of magnitude) for quantifying trace and abundant analytes.
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High-Speed Acquisition: Up to 20 Hz scan rate, optimized for fast chromatographic separations.
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Flexible Ionization: Compatible with multiple ion sources (ESI, nanoESI, APCI, APPI, MALDI).
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Comprehensive MS/MS: Collision-induced dissociation (CID) with optional ETD for in-depth structural characterization.
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Integrated Software: Works with Bruker Compass, MetaboScape, ProteinScape, and BioPharma Compass for complete data analysis.
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Regulatory Ready: 21 CFR Part 11 compliance support for pharmaceutical and GxP workflows.
Applications:
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Proteomics: High-resolution peptide and protein identification in top-down and bottom-up workflows.
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Metabolomics & Lipidomics: Untargeted and targeted analysis of metabolites and lipids with superior accuracy.
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Pharmaceutical Development: Drug metabolism, pharmacokinetics, impurity profiling, and biologics characterization.
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Biotherapeutics: In-depth analysis of monoclonal antibodies, glycoproteins, and complex biologics.
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Environmental & Food Testing: Trace detection of pollutants, pesticides, and food contaminants.
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Clinical & Biomarker Research: Advanced discovery and validation studies.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Quadrupole Time-of-Flight (QTOF) LC-MS |
| Mass Range | m/z 50 – 20,000 |
| Resolution | >60,000 FWHM |
| Mass Accuracy | <1 ppm (internal calibration) |
| Scan Speed | Up to 20 Hz |
| UHPLC System | Agilent 1290 Infinity II (up to 1300 bar, sub-2 µm particles) |
| Ionization Sources | ESI, nanoESI, APCI, APPI, MALDI |
| Fragmentation Modes | CID, optional ETD |
| Dynamic Range | >5 orders of magnitude |
| Software | Compass DataAnalysis, ProteinScape, MetaboScape, BioPharma Compass |
| Compliance | 21 CFR Part 11 ready |