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Bruker maXis Q-TOF with Agilent 1290 Infinity II UHPLC advanced high-resolution LC-MS/MS system for proteomics, metabolomics, pharmaceuticals, and biopharma analysis.

Key Features:

  • High-Resolution QTOF MS: Bruker maXis delivers >60,000 FWHM resolution with sub-ppm mass accuracy for advanced research.

  • Fast UHPLC Separation: Integrated with Agilent 1290 Infinity II UHPLC for ultra-high pressure liquid chromatography (up to 1300 bar) ensuring sharp peaks and high throughput.

  • Accurate Quantification: Broad dynamic range (>5 orders of magnitude) for quantifying trace and abundant analytes.

  • High-Speed Acquisition: Up to 20 Hz scan rate, optimized for fast chromatographic separations.

  • Flexible Ionization: Compatible with multiple ion sources (ESI, nanoESI, APCI, APPI, MALDI).

  • Comprehensive MS/MS: Collision-induced dissociation (CID) with optional ETD for in-depth structural characterization.

  • Integrated Software: Works with Bruker Compass, MetaboScape, ProteinScape, and BioPharma Compass for complete data analysis.

  • Regulatory Ready: 21 CFR Part 11 compliance support for pharmaceutical and GxP workflows.


Applications:

  • Proteomics: High-resolution peptide and protein identification in top-down and bottom-up workflows.

  • Metabolomics & Lipidomics: Untargeted and targeted analysis of metabolites and lipids with superior accuracy.

  • Pharmaceutical Development: Drug metabolism, pharmacokinetics, impurity profiling, and biologics characterization.

  • Biotherapeutics: In-depth analysis of monoclonal antibodies, glycoproteins, and complex biologics.

  • Environmental & Food Testing: Trace detection of pollutants, pesticides, and food contaminants.

  • Clinical & Biomarker Research: Advanced discovery and validation studies.


Specifications (Table):

Parameter Specification
MS Type Quadrupole Time-of-Flight (QTOF) LC-MS
Mass Range m/z 50 – 20,000
Resolution >60,000 FWHM
Mass Accuracy <1 ppm (internal calibration)
Scan Speed Up to 20 Hz
UHPLC System Agilent 1290 Infinity II (up to 1300 bar, sub-2 µm particles)
Ionization Sources ESI, nanoESI, APCI, APPI, MALDI
Fragmentation Modes CID, optional ETD
Dynamic Range >5 orders of magnitude
Software Compass DataAnalysis, ProteinScape, MetaboScape, BioPharma Compass
Compliance 21 CFR Part 11 ready

 

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