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Bruker micrOTOF-Q II LC-MS/MS with Agilent 1200 HPLC high-resolution quadrupole TOF LC-MS system for proteomics, metabolomics, pharmaceuticals, and advanced research applications.

Key Features:

  • Hybrid LC-MS/MS Platform: Combines the Bruker micrOTOF-Q II high-resolution QTOF MS with the reliable Agilent 1200 HPLC system.

  • High-Resolution Accurate Mass (HRAM): Sub-ppm accuracy for molecular formula confirmation in complex mixtures.

  • Seamless LC-MS Integration: Agilent 1200 HPLC ensures precise separations with robust solvent delivery and sample handling.

  • True Isotopic Fidelity (TIF): Accurately reproduces isotope distributions for unambiguous compound identification.

  • Wide Dynamic Range: Detects both trace-level and high-abundance compounds in a single run.

  • Fast Scan Speed: Captures MS and MS/MS spectra at high rates for high-throughput workflows.

  • Flexible Ionization Sources: ESI/APCI options for diverse applications.

  • Comprehensive Software: Compatible with Bruker Compass, DataAnalysis, and ProteinScape for LC-MS/MS workflows.

  • Regulatory Ready: 21 CFR Part 11 compliance for regulated environments.


Applications:

  • Pharmaceutical & Drug Development: Impurity profiling, metabolite identification, structural elucidation.

  • Proteomics & Biomarker Discovery: High-resolution peptide mapping and protein analysis.

  • Metabolomics & Lipidomics: Sensitive profiling of small molecules in biological samples.

  • Food Safety & Environmental Testing: Detection of contaminants, toxins, and pollutants.

  • Academic & Clinical Research: High-performance LC-QTOF system for broad scientific studies.


Specifications (Table):

Parameter Specification
MS Type Quadrupole Time-of-Flight (QTOF)
Mass Range m/z 50 – 20,000
Resolution >17,500 FWHM
Mass Accuracy <3 ppm (external), <1 ppm (internal)
Ionization Source Electrospray Ionization (ESI), optional APCI
HPLC System Agilent 1200 Series HPLC (binary/quaternary pump, autosampler, column oven, DAD)
LC Flow Rate 50 µL/min – 5 mL/min
Acquisition Speed Up to 20 spectra/sec
Dynamic Range >4–5 orders of magnitude
Software Compass, DataAnalysis, ProteinScape
Compliance 21 CFR Part 11 ready
Special Feature True Isotopic Fidelity (TIF)

 

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