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Key Features:
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Hybrid LC-MS/MS Platform: Combines the Bruker micrOTOF-Q II high-resolution QTOF MS with the reliable Agilent 1200 HPLC system.
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High-Resolution Accurate Mass (HRAM): Sub-ppm accuracy for molecular formula confirmation in complex mixtures.
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Seamless LC-MS Integration: Agilent 1200 HPLC ensures precise separations with robust solvent delivery and sample handling.
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True Isotopic Fidelity (TIF): Accurately reproduces isotope distributions for unambiguous compound identification.
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Wide Dynamic Range: Detects both trace-level and high-abundance compounds in a single run.
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Fast Scan Speed: Captures MS and MS/MS spectra at high rates for high-throughput workflows.
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Flexible Ionization Sources: ESI/APCI options for diverse applications.
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Comprehensive Software: Compatible with Bruker Compass, DataAnalysis, and ProteinScape for LC-MS/MS workflows.
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Regulatory Ready: 21 CFR Part 11 compliance for regulated environments.
Applications:
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Pharmaceutical & Drug Development: Impurity profiling, metabolite identification, structural elucidation.
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Proteomics & Biomarker Discovery: High-resolution peptide mapping and protein analysis.
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Metabolomics & Lipidomics: Sensitive profiling of small molecules in biological samples.
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Food Safety & Environmental Testing: Detection of contaminants, toxins, and pollutants.
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Academic & Clinical Research: High-performance LC-QTOF system for broad scientific studies.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Quadrupole Time-of-Flight (QTOF) |
| Mass Range | m/z 50 – 20,000 |
| Resolution | >17,500 FWHM |
| Mass Accuracy | <3 ppm (external), <1 ppm (internal) |
| Ionization Source | Electrospray Ionization (ESI), optional APCI |
| HPLC System | Agilent 1200 Series HPLC (binary/quaternary pump, autosampler, column oven, DAD) |
| LC Flow Rate | 50 µL/min – 5 mL/min |
| Acquisition Speed | Up to 20 spectra/sec |
| Dynamic Range | >4–5 orders of magnitude |
| Software | Compass, DataAnalysis, ProteinScape |
| Compliance | 21 CFR Part 11 ready |
| Special Feature | True Isotopic Fidelity (TIF) |