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Bruker timsTOF Pro LC-MS/MS – trapped ion mobility QTOF mass spectrometer with PASEF technology for ultra-sensitive proteomics, biomarker discovery, pharmaceutical research, and advanced 4D LC-MS applications.
  • Bruker timsTOF Pro LC-MS/MS – trapped ion mobility QTOF mass spectrometer with PASEF technology for ultra-sensitive proteomics, biomarker discovery, pharmaceutical research, and advanced 4D LC-MS applications.
  • Bruker timsTOF Pro LC-MS/MS – trapped ion mobility QTOF mass spectrometer with PASEF technology for ultra-sensitive proteomics, biomarker discovery, pharmaceutical research, and advanced 4D LC-MS applications.
Bruker timsTOF Pro LC-MS/MS Trapped Ion Mobility QTOF Mass Spectrometer with PASEF Technology for Proteomics
$0.00

Key Features:

  • Trapped Ion Mobility Spectrometry (tims): Adds an orthogonal separation dimension for unmatched analytical clarity in complex biological mixtures.

  • PASEF Technology (Parallel Accumulation Serial Fragmentation): Increases sequencing speed and sensitivity without sacrificing data quality.

  • 4D Proteomics: Integrates ion mobility separation with retention time, m/z, and intensity for deep proteome coverage.

  • Ultra-High Sensitivity: Detects low-abundance peptides with exceptional precision.

  • High Throughput: Identifies thousands of proteins per run, suitable for large-scale proteomics studies.

  • Robust Quantitation: Ideal for label-free quantitation, TMT, iTRAQ, and DIA workflows.

  • Fast Acquisition Rates: Enables comprehensive coverage of complex peptide mixtures in shorter analysis times.

  • Stable Platform: Designed for 24/7 operation in demanding core facility and pharma environments.

  • Advanced Software: Integrated with Bruker’s ProteoScape, PEAKS, MaxQuant, and Spectronaut for advanced data analysis.

  • Regulatory Support: 21 CFR Part 11 compliance for pharmaceutical and clinical labs.

Applications:

  • Proteomics & Biomarker Discovery: High-coverage peptide and protein identification.

  • Clinical & Translational Research: Deep proteome profiling for disease mechanism studies.

  • Pharmaceutical R&D: Drug discovery, pharmacokinetics, and biotherapeutics characterization.

  • Metabolomics & Lipidomics (Extended): Sensitive analysis of small molecules with ion mobility separation.

  • Structural Biology: Conformational studies using ion mobility-resolved mass spectrometry.

  • High-Throughput Quantitative Studies: Population-scale proteomic workflows and precision medicine.

Specifications (Table):

Parameter Specification
MS Type Quadrupole Time-of-Flight (QTOF) with Trapped Ion Mobility Spectrometry (tims)
Special Technology PASEF (Parallel Accumulation Serial Fragmentation)
Mass Range m/z 20 – 20,000
Resolution >60,000 FWHM
Mass Accuracy <1 ppm (internal), <3 ppm (external)
Acquisition Speed Up to >100 Hz with PASEF
Dynamic Range >5 orders of magnitude
Ion Mobility Range 0.6–2.0 Vs/cm² (1/K₀)
Ionization Sources ESI (nanoESI, CaptiveSpray), APCI optional
LC System Compatible with Bruker Elute UHPLC or third-party LC (Agilent, Thermo, Shimadzu, Waters)
Vacuum System Multi-stage turbo pumping system
Software Bruker Compass HyStar, ProteoScape, MaxQuant, PEAKS, Spectronaut
Compliance 21 CFR Part 11 support
Key Advantage 4D proteomics with ion mobility separation and PASEF fragmentation

 

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