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SCIEX 5500 Triple Quad LC-MS/MS with Agilent 1290 Infinity II UHPLC  ultra-sensitive, high-throughput quantitative LC-MS/MS system for pharmaceutical, food safety, environmental, and clinical laboratories.

Key Features:

  • Ultra-Sensitive Quantitation: Industry-proven SCIEX 5500 Triple Quad delivers superior sensitivity and reproducibility for trace-level detection.

  • Integrated UHPLC-MS Solution: Agilent 1290 Infinity II UHPLC provides high-resolution chromatographic separation with precise flow control.

  • Fast Polarity Switching: <20 ms to capture both positive and negative ions in a single run.

  • Dynamic MRM (dMRM): Automatically manages dwell and cycle times for multi-compound targeted panels.

  • Enhanced Ion Path: Optimized collision cell (LINAC® technology) for faster, cleaner transitions and reduced crosstalk.

  • Turbo V™ Source Compatibility: Supports a wide range of flow rates for small molecules and biomolecules.

  • Rugged High-Throughput System: Designed for continuous operation in demanding regulated environments.

  • Wide Linear Dynamic Range: Quantifies from trace-level to high-abundance analytes with accuracy.

  • Regulatory Ready: Full support for 21 CFR Part 11 compliance, GLP/GMP validation.

  • UHPLC Flexibility: Infinity II autosampler and column modules support diverse workflows with low carryover.


Applications:

  • Pharmaceutical R&D: Drug metabolism studies, pharmacokinetics, and impurity profiling.

  • Food & Beverage Safety: Residue analysis for pesticides, veterinary drugs, mycotoxins, and contaminants.

  • Environmental Testing: Quantification of pollutants, emerging contaminants, and trace organics in water, soil, and air.

  • Clinical & Forensic Research: Toxicology, therapeutic drug monitoring, and forensic drug screening.

  • Biological Research: Targeted metabolomics, lipidomics, and proteomics with high chromatographic resolution.


Specifications (Table):

Parameter Specification
MS Type Triple Quadrupole LC-MS/MS
Mass Range m/z 5 – 2,000
Mass Resolution Unit resolution (0.7 Da FWHM)
Polarity Switching <20 ms
Dynamic Range Linear over 5–6 orders of magnitude
Scan Speed Up to 5,000 Da/sec
Acquisition Modes MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan
Ionization Sources Turbo V™, DuoSpray®, APCI
Collision Cell LINAC® collision cell technology
Vacuum System Dual turbomolecular pumps
UHPLC System Agilent 1290 Infinity II UHPLC
UHPLC Pressure Up to 1,300 bar
UHPLC Flow Rate Range 0.001 – 5.0 mL/min
Column Temperature 10 – 100 °C
Autosampler Agilent 1290 Infinity II – high-capacity, low carryover
Software SCIEX Analyst® (MS), Agilent OpenLab CDS (UHPLC)
Compliance 21 CFR Part 11, GLP/GMP ready


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