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Key Features:
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Ultra-Sensitive Quantitation: Industry-proven SCIEX 5500 Triple Quad delivers superior sensitivity and reproducibility for trace-level detection.
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Integrated UHPLC-MS Solution: Agilent 1290 Infinity II UHPLC provides high-resolution chromatographic separation with precise flow control.
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Fast Polarity Switching: <20 ms to capture both positive and negative ions in a single run.
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Dynamic MRM (dMRM): Automatically manages dwell and cycle times for multi-compound targeted panels.
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Enhanced Ion Path: Optimized collision cell (LINAC® technology) for faster, cleaner transitions and reduced crosstalk.
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Turbo V™ Source Compatibility: Supports a wide range of flow rates for small molecules and biomolecules.
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Rugged High-Throughput System: Designed for continuous operation in demanding regulated environments.
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Wide Linear Dynamic Range: Quantifies from trace-level to high-abundance analytes with accuracy.
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Regulatory Ready: Full support for 21 CFR Part 11 compliance, GLP/GMP validation.
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UHPLC Flexibility: Infinity II autosampler and column modules support diverse workflows with low carryover.
Applications:
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Pharmaceutical R&D: Drug metabolism studies, pharmacokinetics, and impurity profiling.
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Food & Beverage Safety: Residue analysis for pesticides, veterinary drugs, mycotoxins, and contaminants.
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Environmental Testing: Quantification of pollutants, emerging contaminants, and trace organics in water, soil, and air.
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Clinical & Forensic Research: Toxicology, therapeutic drug monitoring, and forensic drug screening.
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Biological Research: Targeted metabolomics, lipidomics, and proteomics with high chromatographic resolution.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Triple Quadrupole LC-MS/MS |
| Mass Range | m/z 5 – 2,000 |
| Mass Resolution | Unit resolution (0.7 Da FWHM) |
| Polarity Switching | <20 ms |
| Dynamic Range | Linear over 5–6 orders of magnitude |
| Scan Speed | Up to 5,000 Da/sec |
| Acquisition Modes | MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan |
| Ionization Sources | Turbo V™, DuoSpray®, APCI |
| Collision Cell | LINAC® collision cell technology |
| Vacuum System | Dual turbomolecular pumps |
| UHPLC System | Agilent 1290 Infinity II UHPLC |
| UHPLC Pressure | Up to 1,300 bar |
| UHPLC Flow Rate Range | 0.001 – 5.0 mL/min |
| Column Temperature | 10 – 100 °C |
| Autosampler | Agilent 1290 Infinity II – high-capacity, low carryover |
| Software | SCIEX Analyst® (MS), Agilent OpenLab CDS (UHPLC) |
| Compliance | 21 CFR Part 11, GLP/GMP ready |