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SCIEX 5500 Triple Quad LC-MS/MS with ExionLC AD UHPLC  ultra-sensitive, high-throughput quantitative LC-MS/MS system for pharmaceutical, food safety, environmental, and clinical laboratories.

Key Features:

  • Ultra-Sensitive Quantitation: SCIEX 5500 Triple Quad delivers industry-proven sensitivity for trace-level analyte detection.

  • Integrated SCIEX Workflow: Seamless pairing of the ExionLC AD UHPLC with the 5500 system ensures stable and reproducible LC-MS/MS performance.

  • High-Speed UHPLC Separation: ExionLC AD supports up to 1,300 bar pressure for ultra-high-resolution separations and sharp peak shapes.

  • Fast Polarity Switching: <20 ms for simultaneous monitoring of positive and negative ions.

  • Dynamic MRM (dMRM): Optimizes dwell and cycle times for multi-analyte targeted methods.

  • Enhanced Collision Cell: LINAC® technology provides reduced crosstalk and faster ion transmission.

  • Robust Turbo V™ Source: Flexible for a wide range of flow rates and compatible with DuoSpray® and APCI.

  • Wide Linear Dynamic Range: Quantifies across 5–6 orders of magnitude with excellent accuracy.

  • Regulatory Compliance: 21 CFR Part 11 support for data integrity and GLP/GMP-ready workflows.

  • High-Throughput Operation: Designed for continuous performance in demanding pharmaceutical, food, and environmental labs.


Applications:

  • Pharmaceutical R&D & QA/QC: Pharmacokinetics, drug metabolism, impurity profiling, and bioanalysis.

  • Food Safety & Beverage Testing: Pesticides, veterinary drugs, mycotoxins, and contaminants.

  • Environmental Monitoring: Quantification of pollutants, trace organic compounds, and emerging contaminants.

  • Clinical & Forensic Research: Therapeutic drug monitoring, toxicology screening, and forensic investigations.

  • Omics Studies: Targeted metabolomics, lipidomics, and proteomics with high chromatographic resolution.


Specifications (Table):

Parameter Specification
MS Type Triple Quadrupole LC-MS/MS
Mass Range m/z 5 – 2,000
Mass Resolution Unit resolution (0.7 Da FWHM)
Polarity Switching <20 ms
Dynamic Range 5–6 orders of magnitude
Scan Speed Up to 5,000 Da/sec
Acquisition Modes MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan
Ionization Sources Turbo V™, DuoSpray®, APCI
Collision Cell LINAC® collision cell technology
Vacuum System Dual turbomolecular pumps
UHPLC System ExionLC AD UHPLC
UHPLC Pressure Up to 1,300 bar
Flow Rate Range 0.001 – 5.0 mL/min
Column Temperature 10 – 100 °C
Autosampler ExionLC AD with high-capacity trays and low carryover design
Software SCIEX Analyst® Software with full LC-MS/MS integration
Compliance 21 CFR Part 11, GLP/GMP ready


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