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Key Features:
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Ultra-Sensitive Quantitation: SCIEX 6500+ achieves sub-femtogram detection limits, ensuring reliable data for the most demanding applications.
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ExionLC AD UHPLC Integration: Fully compatible UHPLC with 1,300 bar pressure capacity for ultra-sharp peaks, excellent reproducibility, and high throughput.
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OptiFlow® Turbo V Source: Supports both standard-flow and microflow LC, enhancing sensitivity and flexibility.
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SelexION® Differential Ion Mobility (optional): Adds another dimension of selectivity by separating isobaric interferences before MS detection.
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Ultra-Fast Polarity Switching: <5 ms, enabling efficient acquisition in workflows requiring both positive and negative ions.
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MRM Power: Capable of up to 5,000 MRM transitions/sec for multiplexed assays with precise quantitation.
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Wide Dynamic Range: Linear over 6+ orders of magnitude, enabling simultaneous quantification of high- and low-abundance analytes.
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High Robustness: LINAC® collision cell technology minimizes crosstalk, delivering reproducible results even in complex matrices.
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Regulatory Ready: Supports 21 CFR Part 11 compliance for data integrity in GLP/GMP-regulated labs.
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SCIEX OS & Analyst® Software: Simplified workflows with compliance-ready data acquisition, processing, and reporting.
Applications:
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Pharmaceutical & Biopharma: Pharmacokinetics, drug metabolism, DMPK studies, impurity profiling, and bioequivalence testing.
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Bioanalytical CROs: High-throughput targeted quantitation for clinical trial sample analysis.
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Food Safety & Agriculture: Detection of pesticides, veterinary drugs, mycotoxins, and contaminants at ultra-trace levels.
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Environmental Testing: Monitoring persistent organic pollutants, trace contaminants, and emerging chemicals in complex samples.
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Clinical & Forensic Research: Toxicology, therapeutic drug monitoring, forensic drug screening, and clinical research assays.
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Targeted Omics Research: Metabolomics, lipidomics, and proteomics requiring extreme sensitivity and dynamic range.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Triple Quadrupole LC-MS/MS |
| Mass Range | m/z 5 – 2,000 |
| Resolution | Unit resolution (0.7 Da FWHM) |
| Polarity Switching | <5 ms |
| Dynamic Range | >6 orders of magnitude |
| MRM Transitions | Up to 5,000 transitions/sec |
| Acquisition Modes | MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan |
| Ionization Sources | Turbo V™, OptiFlow® Turbo V, DuoSpray®, APCI |
| SelexION® Technology | Optional – Differential Ion Mobility for improved selectivity |
| Collision Cell | LINAC® collision cell technology |
| Vacuum System | Dual turbomolecular pumps |
| UHPLC System | ExionLC AD UHPLC |
| UHPLC Pressure | Up to 1,300 bar |
| Flow Rate Range | 0.001 – 5.0 mL/min |
| Column Temperature | 10 – 100 °C |
| Autosampler | ExionLC AD – high capacity, low carryover |
| Software | Analyst® Software, SCIEX OS |
| Compliance | 21 CFR Part 11, GLP/GMP ready |