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SCIEX 6500+ Triple Quad LC-MS/MS with ExionLC AD UHPLC  ultra-sensitive, high-throughput LC-MS/MS system for pharmaceutical bioanalysis, clinical toxicology, food safety, and environmental testing.

Key Features:

  • Ultra-Sensitive Quantitation: SCIEX 6500+ achieves sub-femtogram detection limits, ensuring reliable data for the most demanding applications.

  • ExionLC AD UHPLC Integration: Fully compatible UHPLC with 1,300 bar pressure capacity for ultra-sharp peaks, excellent reproducibility, and high throughput.

  • OptiFlow® Turbo V Source: Supports both standard-flow and microflow LC, enhancing sensitivity and flexibility.

  • SelexION® Differential Ion Mobility (optional): Adds another dimension of selectivity by separating isobaric interferences before MS detection.

  • Ultra-Fast Polarity Switching: <5 ms, enabling efficient acquisition in workflows requiring both positive and negative ions.

  • MRM Power: Capable of up to 5,000 MRM transitions/sec for multiplexed assays with precise quantitation.

  • Wide Dynamic Range: Linear over 6+ orders of magnitude, enabling simultaneous quantification of high- and low-abundance analytes.

  • High Robustness: LINAC® collision cell technology minimizes crosstalk, delivering reproducible results even in complex matrices.

  • Regulatory Ready: Supports 21 CFR Part 11 compliance for data integrity in GLP/GMP-regulated labs.

  • SCIEX OS & Analyst® Software: Simplified workflows with compliance-ready data acquisition, processing, and reporting.


Applications:

  • Pharmaceutical & Biopharma: Pharmacokinetics, drug metabolism, DMPK studies, impurity profiling, and bioequivalence testing.

  • Bioanalytical CROs: High-throughput targeted quantitation for clinical trial sample analysis.

  • Food Safety & Agriculture: Detection of pesticides, veterinary drugs, mycotoxins, and contaminants at ultra-trace levels.

  • Environmental Testing: Monitoring persistent organic pollutants, trace contaminants, and emerging chemicals in complex samples.

  • Clinical & Forensic Research: Toxicology, therapeutic drug monitoring, forensic drug screening, and clinical research assays.

  • Targeted Omics Research: Metabolomics, lipidomics, and proteomics requiring extreme sensitivity and dynamic range.


Specifications (Table):

Parameter Specification
MS Type Triple Quadrupole LC-MS/MS
Mass Range m/z 5 – 2,000
Resolution Unit resolution (0.7 Da FWHM)
Polarity Switching <5 ms
Dynamic Range >6 orders of magnitude
MRM Transitions Up to 5,000 transitions/sec
Acquisition Modes MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan
Ionization Sources Turbo V™, OptiFlow® Turbo V, DuoSpray®, APCI
SelexION® Technology Optional – Differential Ion Mobility for improved selectivity
Collision Cell LINAC® collision cell technology
Vacuum System Dual turbomolecular pumps
UHPLC System ExionLC AD UHPLC
UHPLC Pressure Up to 1,300 bar
Flow Rate Range 0.001 – 5.0 mL/min
Column Temperature 10 – 100 °C
Autosampler ExionLC AD – high capacity, low carryover
Software Analyst® Software, SCIEX OS
Compliance 21 CFR Part 11, GLP/GMP ready


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