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Key Features:
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Next-Generation Sensitivity: SCIEX 7500 delivers up to 10× greater sensitivity over previous SCIEX Triple Quad systems, ensuring ultra-trace quantitation for regulated assays.
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Agilent 1290 Infinity II UHPLC Integration: Industry-leading 1,200 bar UHPLC system with advanced pump technology, superior gradient precision, and excellent reproducibility.
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OptiFlow® Turbo V Source: Provides compatibility with both high-flow and microflow workflows for maximum flexibility.
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EAO (Electronically Activated Orthogonal Accelerator): Enhances ion focusing and improves transmission efficiency, boosting signal intensity.
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SelexION+ Differential Ion Mobility (optional): Adds orthogonal gas-phase separation to increase selectivity for complex sample matrices.
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Fast Polarity Switching: <5 ms, ideal for multi-class compound analysis.
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High-Speed MRM Acquisition: Supports up to 5,000 MRM transitions/sec, enabling large-scale targeted assays with accuracy.
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Wide Linear Dynamic Range: More than 6 orders of magnitude, supporting quantitation of both trace-level and abundant analytes.
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Robustness for High-Throughput Labs: Enhanced LINAC® collision cell design reduces crosstalk and ensures reproducibility.
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Regulatory-Ready Platform: Fully compliant with 21 CFR Part 11 for GLP/GMP-regulated environments.
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Software Ecosystem: SCIEX OS and Analyst® software for data acquisition, quantitation, compliance, and secure reporting.
Applications:
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Pharmaceutical & Biopharma: Pharmacokinetic studies, drug metabolism (DMPK), bioequivalence testing, and impurity profiling.
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Clinical & Forensic Research: Therapeutic drug monitoring, forensic toxicology, and clinical pharmacology assays.
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Contract Research Organizations (CROs): High-throughput regulated bioanalytical workflows for drug development pipelines.
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Food Safety & Agriculture: Quantitative detection of pesticides, mycotoxins, veterinary drugs, and contaminants at ultra-trace levels.
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Environmental Testing: Quantification of pollutants, pharmaceuticals, and emerging contaminants in complex samples.
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Targeted Omics: Metabolomics and lipidomics requiring extreme sensitivity and high reproducibility.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Triple Quadrupole LC-MS/MS |
| Mass Range | m/z 5 – 2,000 |
| Resolution | Unit resolution (0.7 Da FWHM) |
| Polarity Switching | <5 ms |
| Dynamic Range | >6 orders of magnitude |
| MRM Transitions | Up to 5,000 transitions/sec |
| Acquisition Modes | MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan |
| Ionization Sources | Turbo V™, OptiFlow® Turbo V, DuoSpray®, APCI |
| SelexION+ Technology | Optional – Differential Ion Mobility |
| Collision Cell | Enhanced LINAC® collision cell |
| Vacuum System | Dual turbomolecular pumps |
| UHPLC System | Agilent 1290 Infinity II UHPLC |
| UHPLC Pressure | Up to 1,200 bar |
| Flow Rate Range | 0.001 – 5.0 mL/min |
| Column Temperature | 10 – 100 °C |
| Autosampler | Agilent 1290 Infinity II autosampler, high-capacity, ultra-low carryover |
| Software | Analyst®, SCIEX OS |
| Compliance | 21 CFR Part 11, GLP/GMP ready |