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SCIEX 7500 Triple Quad LC-MS/MS with Agilent 1290 Infinity II UHPLC ultra-sensitive, high-throughput quantitative LC-MS/MS system for pharmaceutical bioanalysis, clinical toxicology, food safety, and environmental testing.

Key Features:

  • Next-Generation Sensitivity: SCIEX 7500 delivers up to 10× greater sensitivity over previous SCIEX Triple Quad systems, ensuring ultra-trace quantitation for regulated assays.

  • Agilent 1290 Infinity II UHPLC Integration: Industry-leading 1,200 bar UHPLC system with advanced pump technology, superior gradient precision, and excellent reproducibility.

  • OptiFlow® Turbo V Source: Provides compatibility with both high-flow and microflow workflows for maximum flexibility.

  • EAO (Electronically Activated Orthogonal Accelerator): Enhances ion focusing and improves transmission efficiency, boosting signal intensity.

  • SelexION+ Differential Ion Mobility (optional): Adds orthogonal gas-phase separation to increase selectivity for complex sample matrices.

  • Fast Polarity Switching: <5 ms, ideal for multi-class compound analysis.

  • High-Speed MRM Acquisition: Supports up to 5,000 MRM transitions/sec, enabling large-scale targeted assays with accuracy.

  • Wide Linear Dynamic Range: More than 6 orders of magnitude, supporting quantitation of both trace-level and abundant analytes.

  • Robustness for High-Throughput Labs: Enhanced LINAC® collision cell design reduces crosstalk and ensures reproducibility.

  • Regulatory-Ready Platform: Fully compliant with 21 CFR Part 11 for GLP/GMP-regulated environments.

  • Software Ecosystem: SCIEX OS and Analyst® software for data acquisition, quantitation, compliance, and secure reporting.


Applications:

  • Pharmaceutical & Biopharma: Pharmacokinetic studies, drug metabolism (DMPK), bioequivalence testing, and impurity profiling.

  • Clinical & Forensic Research: Therapeutic drug monitoring, forensic toxicology, and clinical pharmacology assays.

  • Contract Research Organizations (CROs): High-throughput regulated bioanalytical workflows for drug development pipelines.

  • Food Safety & Agriculture: Quantitative detection of pesticides, mycotoxins, veterinary drugs, and contaminants at ultra-trace levels.

  • Environmental Testing: Quantification of pollutants, pharmaceuticals, and emerging contaminants in complex samples.

  • Targeted Omics: Metabolomics and lipidomics requiring extreme sensitivity and high reproducibility.


Specifications (Table):

Parameter Specification
MS Type Triple Quadrupole LC-MS/MS
Mass Range m/z 5 – 2,000
Resolution Unit resolution (0.7 Da FWHM)
Polarity Switching <5 ms
Dynamic Range >6 orders of magnitude
MRM Transitions Up to 5,000 transitions/sec
Acquisition Modes MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan
Ionization Sources Turbo V™, OptiFlow® Turbo V, DuoSpray®, APCI
SelexION+ Technology Optional – Differential Ion Mobility
Collision Cell Enhanced LINAC® collision cell
Vacuum System Dual turbomolecular pumps
UHPLC System Agilent 1290 Infinity II UHPLC
UHPLC Pressure Up to 1,200 bar
Flow Rate Range 0.001 – 5.0 mL/min
Column Temperature 10 – 100 °C
Autosampler Agilent 1290 Infinity II autosampler, high-capacity, ultra-low carryover
Software Analyst®, SCIEX OS
Compliance 21 CFR Part 11, GLP/GMP ready


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