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SCIEX 7500 Triple Quad LC-MS/MS with ExionLC AD UHPLC  ultra-sensitive quantitative LC-MS/MS system for pharmaceutical bioanalysis, clinical toxicology, food safety, and environmental testing.

Key Features:

  • Next-Generation Sensitivity: SCIEX 7500 achieves up to 10× higher sensitivity compared to prior SCIEX Triple Quads, enabling femtogram-level quantitation.

  • OptiFlow® Turbo V Source: Flexible ionization source for both microflow and analytical flow applications with improved robustness.

  • ExionLC AD UHPLC Integration: Delivers 1,300 bar pressure, rapid gradients, superior reproducibility, and minimal carryover.

  • Electronically Activated Orthogonal Accelerator (EAO): Enhances ion transmission efficiency for increased signal intensity.

  • SelexION+ Technology (optional): Differential ion mobility for higher selectivity in complex matrices.

  • Fast Polarity Switching: <5 ms for simultaneous positive/negative ion detection.

  • High-Speed Acquisition: Capable of up to 5,000 MRM transitions/sec, supporting multiplexed assays without loss of performance.

  • Wide Linear Dynamic Range: Spanning 6+ orders of magnitude for both low- and high-abundance analytes.

  • Robust Collision Cell: Enhanced LINAC® design reduces crosstalk and increases quantitation reliability.

  • Regulatory-Ready: Supports 21 CFR Part 11 compliance, making it suitable for GLP/GMP-regulated workflows.

  • Powerful Software: SCIEX OS and Analyst® software streamline acquisition, analysis, and secure reporting.


Applications:

  • Pharmaceutical & Biopharma: Pharmacokinetics, DMPK, metabolite profiling, and impurity analysis.

  • Bioanalytical CROs: Ultra-sensitive regulated bioanalytical testing with high throughput.

  • Clinical & Forensic Research: Therapeutic drug monitoring, forensic toxicology, and clinical pharmacology assays.

  • Food Safety & Agriculture: Trace-level detection of pesticides, mycotoxins, veterinary drugs, and food contaminants.

  • Environmental Analysis: Quantitation of trace pollutants, pharmaceuticals, and emerging contaminants in water and soil.

  • Targeted Omics: Highly sensitive metabolomics, lipidomics, and biomarker discovery.


Specifications (Table):

Parameter Specification
MS Type Triple Quadrupole LC-MS/MS
Mass Range m/z 5 – 2,000
Resolution Unit resolution (0.7 Da FWHM)
Polarity Switching <5 ms
Dynamic Range >6 orders of magnitude
MRM Transitions Up to 5,000 transitions/sec
Acquisition Modes MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan
Ionization Sources Turbo V™, OptiFlow® Turbo V, DuoSpray®, APCI
SelexION+ Technology Optional – Differential Ion Mobility
Collision Cell Enhanced LINAC® collision cell
Vacuum System Dual turbomolecular pumps
UHPLC System ExionLC AD UHPLC
UHPLC Pressure Up to 1,300 bar
Flow Rate Range 0.001 – 5.0 mL/min
Column Temperature 10 – 100 °C
Autosampler ExionLC AD autosampler, high capacity, ultra-low carryover
Software Analyst®, SCIEX OS
Compliance 21 CFR Part 11, GLP/GMP ready



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