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Key Features:
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Next-Generation Sensitivity: SCIEX 7500 achieves up to 10× higher sensitivity compared to prior SCIEX Triple Quads, enabling femtogram-level quantitation.
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OptiFlow® Turbo V Source: Flexible ionization source for both microflow and analytical flow applications with improved robustness.
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ExionLC AD UHPLC Integration: Delivers 1,300 bar pressure, rapid gradients, superior reproducibility, and minimal carryover.
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Electronically Activated Orthogonal Accelerator (EAO): Enhances ion transmission efficiency for increased signal intensity.
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SelexION+ Technology (optional): Differential ion mobility for higher selectivity in complex matrices.
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Fast Polarity Switching: <5 ms for simultaneous positive/negative ion detection.
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High-Speed Acquisition: Capable of up to 5,000 MRM transitions/sec, supporting multiplexed assays without loss of performance.
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Wide Linear Dynamic Range: Spanning 6+ orders of magnitude for both low- and high-abundance analytes.
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Robust Collision Cell: Enhanced LINAC® design reduces crosstalk and increases quantitation reliability.
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Regulatory-Ready: Supports 21 CFR Part 11 compliance, making it suitable for GLP/GMP-regulated workflows.
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Powerful Software: SCIEX OS and Analyst® software streamline acquisition, analysis, and secure reporting.
Applications:
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Pharmaceutical & Biopharma: Pharmacokinetics, DMPK, metabolite profiling, and impurity analysis.
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Bioanalytical CROs: Ultra-sensitive regulated bioanalytical testing with high throughput.
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Clinical & Forensic Research: Therapeutic drug monitoring, forensic toxicology, and clinical pharmacology assays.
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Food Safety & Agriculture: Trace-level detection of pesticides, mycotoxins, veterinary drugs, and food contaminants.
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Environmental Analysis: Quantitation of trace pollutants, pharmaceuticals, and emerging contaminants in water and soil.
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Targeted Omics: Highly sensitive metabolomics, lipidomics, and biomarker discovery.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Triple Quadrupole LC-MS/MS |
| Mass Range | m/z 5 – 2,000 |
| Resolution | Unit resolution (0.7 Da FWHM) |
| Polarity Switching | <5 ms |
| Dynamic Range | >6 orders of magnitude |
| MRM Transitions | Up to 5,000 transitions/sec |
| Acquisition Modes | MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan |
| Ionization Sources | Turbo V™, OptiFlow® Turbo V, DuoSpray®, APCI |
| SelexION+ Technology | Optional – Differential Ion Mobility |
| Collision Cell | Enhanced LINAC® collision cell |
| Vacuum System | Dual turbomolecular pumps |
| UHPLC System | ExionLC AD UHPLC |
| UHPLC Pressure | Up to 1,300 bar |
| Flow Rate Range | 0.001 – 5.0 mL/min |
| Column Temperature | 10 – 100 °C |
| Autosampler | ExionLC AD autosampler, high capacity, ultra-low carryover |
| Software | Analyst®, SCIEX OS |
| Compliance | 21 CFR Part 11, GLP/GMP ready |