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SCIEX 7500 Triple Quad LC-MS/MS with Shimadzu Nexera UHPLC robust, high-performance, ultra-sensitive LC-MS/MS system for pharmaceutical research, clinical toxicology, food safety, and environmental analysis.

Key Features:

  • SCIEX 7500 Sensitivity Boost: Up to 10× greater sensitivity than previous generations, delivering ultra-trace level quantitation.

  • Shimadzu Nexera UHPLC Integration: High-pressure (up to 1,300 bar) liquid chromatography system offering exceptional flow precision, reproducibility, and robustness for extended use.

  • Turbo V™ & OptiFlow® Ion Sources: Flexible ionization options for high-flow and microflow applications.

  • SelexION+ Differential Ion Mobility (optional): Adds enhanced selectivity for complex biological and environmental matrices.

  • Fast Polarity Switching: <5 ms for efficient multi-analyte workflows.

  • High-Speed MRM: Up to 5,000 transitions/sec, supporting large-scale targeted quantitation.

  • Dynamic Range: >6 orders of magnitude for simultaneous detection of trace and abundant compounds.

  • Robust Collision Cell Design: Enhanced LINAC® cell for reduced crosstalk and consistent results.

  • Data Integrity & Compliance: Compatible with 21 CFR Part 11 requirements for regulated workflows.

  • Software Ecosystem: SCIEX OS and Analyst® software for acquisition, quantitation, and compliance.


Applications:

  • Pharmaceutical & Biopharma: Drug metabolism (DMPK), pharmacokinetics, impurity quantification, and bioequivalence studies.

  • Clinical & Forensic Research: Therapeutic drug monitoring, forensic toxicology, and diagnostic assay development.

  • CRO & Regulated Bioanalysis: High-throughput quantitative workflows with strict reproducibility demands.

  • Food Safety & Agriculture: Ultra-trace detection of pesticides, mycotoxins, contaminants, and veterinary residues.

  • Environmental Monitoring: Quantitative analysis of pollutants, pharmaceuticals, and emerging contaminants in complex matrices.

  • Targeted Omics: Sensitive metabolomics, lipidomics, and biomarker quantitation.


Specifications (Table):

Parameter Specification
MS Type Triple Quadrupole LC-MS/MS
Mass Range m/z 5 – 2,000
Resolution Unit resolution (0.7 Da FWHM)
Polarity Switching <5 ms
Dynamic Range >6 orders of magnitude
MRM Transitions Up to 5,000/sec
Acquisition Modes MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan
Ionization Sources Turbo V™, OptiFlow®, DuoSpray®, APCI
SelexION+ Optional – Differential Ion Mobility
Collision Cell Enhanced LINAC® collision cell
Vacuum System Dual turbomolecular pumps
UHPLC System Shimadzu Nexera UHPLC
UHPLC Pressure Up to 1,300 bar
Flow Rate Range 0.001 – 5.0 mL/min
Column Temperature 5 – 90 °C
Autosampler Nexera autosampler with high-capacity trays, low carryover
Software Analyst®, SCIEX OS
Compliance 21 CFR Part 11, GLP/GMP ready


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