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Key Features:
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SCIEX 7500 Sensitivity Boost: Up to 10× greater sensitivity than previous generations, delivering ultra-trace level quantitation.
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Shimadzu Nexera UHPLC Integration: High-pressure (up to 1,300 bar) liquid chromatography system offering exceptional flow precision, reproducibility, and robustness for extended use.
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Turbo V™ & OptiFlow® Ion Sources: Flexible ionization options for high-flow and microflow applications.
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SelexION+ Differential Ion Mobility (optional): Adds enhanced selectivity for complex biological and environmental matrices.
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Fast Polarity Switching: <5 ms for efficient multi-analyte workflows.
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High-Speed MRM: Up to 5,000 transitions/sec, supporting large-scale targeted quantitation.
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Dynamic Range: >6 orders of magnitude for simultaneous detection of trace and abundant compounds.
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Robust Collision Cell Design: Enhanced LINAC® cell for reduced crosstalk and consistent results.
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Data Integrity & Compliance: Compatible with 21 CFR Part 11 requirements for regulated workflows.
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Software Ecosystem: SCIEX OS and Analyst® software for acquisition, quantitation, and compliance.
Applications:
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Pharmaceutical & Biopharma: Drug metabolism (DMPK), pharmacokinetics, impurity quantification, and bioequivalence studies.
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Clinical & Forensic Research: Therapeutic drug monitoring, forensic toxicology, and diagnostic assay development.
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CRO & Regulated Bioanalysis: High-throughput quantitative workflows with strict reproducibility demands.
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Food Safety & Agriculture: Ultra-trace detection of pesticides, mycotoxins, contaminants, and veterinary residues.
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Environmental Monitoring: Quantitative analysis of pollutants, pharmaceuticals, and emerging contaminants in complex matrices.
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Targeted Omics: Sensitive metabolomics, lipidomics, and biomarker quantitation.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Triple Quadrupole LC-MS/MS |
| Mass Range | m/z 5 – 2,000 |
| Resolution | Unit resolution (0.7 Da FWHM) |
| Polarity Switching | <5 ms |
| Dynamic Range | >6 orders of magnitude |
| MRM Transitions | Up to 5,000/sec |
| Acquisition Modes | MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan |
| Ionization Sources | Turbo V™, OptiFlow®, DuoSpray®, APCI |
| SelexION+ | Optional – Differential Ion Mobility |
| Collision Cell | Enhanced LINAC® collision cell |
| Vacuum System | Dual turbomolecular pumps |
| UHPLC System | Shimadzu Nexera UHPLC |
| UHPLC Pressure | Up to 1,300 bar |
| Flow Rate Range | 0.001 – 5.0 mL/min |
| Column Temperature | 5 – 90 °C |
| Autosampler | Nexera autosampler with high-capacity trays, low carryover |
| Software | Analyst®, SCIEX OS |
| Compliance | 21 CFR Part 11, GLP/GMP ready |