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Key Features:
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Unmatched Sensitivity: SCIEX 7500 delivers up to 10× higher sensitivity than previous-generation triple quads for low-level quantitation.
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Waters Acquity UPLC Integration: Renowned sub-2 µm particle separation technology for high-resolution, reproducible chromatographic performance.
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High-Pressure UPLC: Handles up to 15,000 psi, enabling rapid separations with narrow peaks and enhanced resolution.
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Turbo V™, OptiFlow®, and DuoSpray® Sources: Flexible ionization modes supporting high-flow and microflow workflows.
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Fast Polarity Switching: <5 ms for simultaneous quantitation of positive and negative ions.
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High-Speed MRM Performance: Processes up to 5,000 transitions/sec, ideal for complex bioanalytical assays.
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SelexION+ Option: Differential Ion Mobility Technology for enhanced selectivity in challenging matrices.
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Dynamic Range: >6 orders of magnitude with excellent linearity.
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Waters UPLC Autosampler: Low carryover, temperature control, and high reproducibility for sensitive assays.
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21 CFR Part 11 Ready: Full compliance for regulated workflows with SCIEX OS and Analyst® software.
Applications:
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Pharmaceutical & Biopharma: Drug discovery, ADME/DMPK, bioequivalence, and impurity profiling.
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Clinical & Forensic Research: Therapeutic drug monitoring, toxicology panels, and metabolite ID.
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Contract Research & CROs: High-throughput regulated bioanalysis with reliable reproducibility.
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Food & Beverage Safety: Detection of contaminants, veterinary residues, and food additives.
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Environmental Testing: Trace detection of pesticides, pollutants, and pharmaceuticals in water and soil.
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Omics Research: Targeted metabolomics and lipidomics with precise quantitation.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Triple Quadrupole LC-MS/MS |
| Mass Range | m/z 5 – 2,000 |
| Resolution | Unit resolution (0.7 Da FWHM) |
| Polarity Switching | <5 ms |
| Dynamic Range | >6 orders of magnitude |
| MRM Transitions | Up to 5,000/sec |
| Acquisition Modes | MRM, Full Scan, Product Ion, Precursor Ion, Neutral Loss |
| Ionization Sources | Turbo V™, OptiFlow®, DuoSpray®, APCI |
| SelexION+ | Optional – Differential Ion Mobility |
| Collision Cell | Enhanced LINAC® collision cell |
| Vacuum System | Dual turbomolecular pumps |
| UPLC System | Waters Acquity UPLC |
| UPLC Pressure | Up to 15,000 psi |
| Flow Rate Range | 0.001 – 2.0 mL/min |
| Column Temperature | 5 – 65 °C |
| Autosampler | Acquity UPLC autosampler with temperature control and minimal carryover |
| Software | Analyst®, SCIEX OS |
| Compliance | 21 CFR Part 11, GLP/GMP ready |