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SCIEX 7500 Triple Quad LC-MS/MS with Waters Acquity UPLC ultra-sensitive quantitative LC-MS/MS system for pharmaceutical, clinical, food safety, and environmental applications.

Key Features:

  • Unmatched Sensitivity: SCIEX 7500 delivers up to 10× higher sensitivity than previous-generation triple quads for low-level quantitation.

  • Waters Acquity UPLC Integration: Renowned sub-2 µm particle separation technology for high-resolution, reproducible chromatographic performance.

  • High-Pressure UPLC: Handles up to 15,000 psi, enabling rapid separations with narrow peaks and enhanced resolution.

  • Turbo V™, OptiFlow®, and DuoSpray® Sources: Flexible ionization modes supporting high-flow and microflow workflows.

  • Fast Polarity Switching: <5 ms for simultaneous quantitation of positive and negative ions.

  • High-Speed MRM Performance: Processes up to 5,000 transitions/sec, ideal for complex bioanalytical assays.

  • SelexION+ Option: Differential Ion Mobility Technology for enhanced selectivity in challenging matrices.

  • Dynamic Range: >6 orders of magnitude with excellent linearity.

  • Waters UPLC Autosampler: Low carryover, temperature control, and high reproducibility for sensitive assays.

  • 21 CFR Part 11 Ready: Full compliance for regulated workflows with SCIEX OS and Analyst® software.


Applications:

  • Pharmaceutical & Biopharma: Drug discovery, ADME/DMPK, bioequivalence, and impurity profiling.

  • Clinical & Forensic Research: Therapeutic drug monitoring, toxicology panels, and metabolite ID.

  • Contract Research & CROs: High-throughput regulated bioanalysis with reliable reproducibility.

  • Food & Beverage Safety: Detection of contaminants, veterinary residues, and food additives.

  • Environmental Testing: Trace detection of pesticides, pollutants, and pharmaceuticals in water and soil.

  • Omics Research: Targeted metabolomics and lipidomics with precise quantitation.


Specifications (Table):

Parameter Specification
MS Type Triple Quadrupole LC-MS/MS
Mass Range m/z 5 – 2,000
Resolution Unit resolution (0.7 Da FWHM)
Polarity Switching <5 ms
Dynamic Range >6 orders of magnitude
MRM Transitions Up to 5,000/sec
Acquisition Modes MRM, Full Scan, Product Ion, Precursor Ion, Neutral Loss
Ionization Sources Turbo V™, OptiFlow®, DuoSpray®, APCI
SelexION+ Optional – Differential Ion Mobility
Collision Cell Enhanced LINAC® collision cell
Vacuum System Dual turbomolecular pumps
UPLC System Waters Acquity UPLC
UPLC Pressure Up to 15,000 psi
Flow Rate Range 0.001 – 2.0 mL/min
Column Temperature 5 – 65 °C
Autosampler Acquity UPLC autosampler with temperature control and minimal carryover
Software Analyst®, SCIEX OS
Compliance 21 CFR Part 11, GLP/GMP ready


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