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SCIEX ZenoTOF 7600 LC-MS/MS with Eksigent nanoLC 425 – ultra-high sensitivity high-resolution QTOF system with Zeno trap technology for proteomics, metabolomics, pharmaceutical research, and biomarker discovery.

Key Features:

  • Zeno Trap Technology: Delivers up to 20× sensitivity enhancement by trapping and pulsing ions into the TOF analyzer, boosting signal for low-abundance analytes.

  • High-Resolution Accurate Mass (HRAM): >40,000 FWHM resolution with <1 ppm accuracy ensures confident compound and biomolecule identification.

  • Ultra-Fast Acquisition: >133 spectra/sec, ideal for high-throughput UHPLC and nanoLC workflows.

  • Eksigent nanoLC 425 Integration: Nano-flow LC system optimized for proteomics, biomarker discovery, and quantitative omics, delivering ultra-low flow precision and stability.

  • Next-Generation SWATH DIA: Improved sensitivity and reproducibility for deep and quantitative proteomic studies.

  • Wide Dynamic Range: >5 orders of magnitude to simultaneously detect low-level biomarkers and highly abundant proteins.

  • Versatile Ionization Sources: Compatible with Turbo V™ and DuoSpray® sources for ESI and APCI workflows.

  • Rapid Polarity Switching: <20 ms for efficient dual-mode workflows.

  • Optimized Optics & Detection: Enhanced ion transmission and stability ensure robust long-term performance.

  • Regulatory Ready: 21 CFR Part 11 support for data integrity in regulated pharma/clinical environments.


Applications:

  • Proteomics: Deep proteome coverage, biomarker discovery, SWATH DIA-based quantitative proteomics at ultra-low sample levels.

  • Metabolomics & Lipidomics: Ultra-sensitive targeted and untargeted profiling of small molecules and lipids.

  • Pharmaceutical R&D: Drug metabolism (DMPK), pharmacokinetics, impurity detection, and lead optimization.

  • Clinical & Translational Research: Biomarker validation, pathway analysis, precision medicine, and large-cohort omics.

  • Food & Environmental Testing: Trace-level screening of pesticides, pollutants, toxins, and contaminants.


Specifications (Table):

Parameter Specification
System Configuration SCIEX ZenoTOF 7600 + Eksigent nanoLC 425
MS Type Hybrid Quadrupole-Time-of-Flight (Q-TOF)
Mass Range m/z ~20 – 40,000
Resolution >40,000 FWHM
Mass Accuracy <1 ppm with internal calibration
Dynamic Range >5 orders of magnitude
Acquisition Speed >133 spectra/sec
Ionization Modes ESI, APCI
Polarity Switching <20 ms
Acquisition Modes Full Scan MS, SWATH DIA, Zeno MS/MS, IDA, MS/MSALL
Sensitivity Up to 20× improved with Zeno trap enabled
Collision Cell Q2 linear accelerator collision cell
Vacuum System Multi-stage turbo molecular pumps
LC Front-End Eksigent nanoLC 425 (nano-flow LC system)
Flow Range nL/min – μL/min nano-flow capability
Autosampler Precision High reproducibility, ultra-low carryover
Interface Turbo V™ Source, optional DuoSpray®
Software SCIEX OS, DIA-NN integration
Compliance 21 CFR Part 11, GLP/GMP ready


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