Pickup currently not available
Key Features:
-
Zeno Trap Technology: Delivers up to 20× sensitivity enhancement by trapping and pulsing ions into the TOF analyzer, boosting signal for low-abundance analytes.
-
High-Resolution Accurate Mass (HRAM): >40,000 FWHM resolution with <1 ppm accuracy ensures confident compound and biomolecule identification.
-
Ultra-Fast Acquisition: >133 spectra/sec, ideal for high-throughput UHPLC and nanoLC workflows.
-
Eksigent nanoLC 425 Integration: Nano-flow LC system optimized for proteomics, biomarker discovery, and quantitative omics, delivering ultra-low flow precision and stability.
-
Next-Generation SWATH DIA: Improved sensitivity and reproducibility for deep and quantitative proteomic studies.
-
Wide Dynamic Range: >5 orders of magnitude to simultaneously detect low-level biomarkers and highly abundant proteins.
-
Versatile Ionization Sources: Compatible with Turbo V™ and DuoSpray® sources for ESI and APCI workflows.
-
Rapid Polarity Switching: <20 ms for efficient dual-mode workflows.
-
Optimized Optics & Detection: Enhanced ion transmission and stability ensure robust long-term performance.
-
Regulatory Ready: 21 CFR Part 11 support for data integrity in regulated pharma/clinical environments.
Applications:
-
Proteomics: Deep proteome coverage, biomarker discovery, SWATH DIA-based quantitative proteomics at ultra-low sample levels.
-
Metabolomics & Lipidomics: Ultra-sensitive targeted and untargeted profiling of small molecules and lipids.
-
Pharmaceutical R&D: Drug metabolism (DMPK), pharmacokinetics, impurity detection, and lead optimization.
-
Clinical & Translational Research: Biomarker validation, pathway analysis, precision medicine, and large-cohort omics.
-
Food & Environmental Testing: Trace-level screening of pesticides, pollutants, toxins, and contaminants.
Specifications (Table):
| Parameter | Specification |
|---|---|
| System Configuration | SCIEX ZenoTOF 7600 + Eksigent nanoLC 425 |
| MS Type | Hybrid Quadrupole-Time-of-Flight (Q-TOF) |
| Mass Range | m/z ~20 – 40,000 |
| Resolution | >40,000 FWHM |
| Mass Accuracy | <1 ppm with internal calibration |
| Dynamic Range | >5 orders of magnitude |
| Acquisition Speed | >133 spectra/sec |
| Ionization Modes | ESI, APCI |
| Polarity Switching | <20 ms |
| Acquisition Modes | Full Scan MS, SWATH DIA, Zeno MS/MS, IDA, MS/MSALL |
| Sensitivity | Up to 20× improved with Zeno trap enabled |
| Collision Cell | Q2 linear accelerator collision cell |
| Vacuum System | Multi-stage turbo molecular pumps |
| LC Front-End | Eksigent nanoLC 425 (nano-flow LC system) |
| Flow Range | nL/min – μL/min nano-flow capability |
| Autosampler Precision | High reproducibility, ultra-low carryover |
| Interface | Turbo V™ Source, optional DuoSpray® |
| Software | SCIEX OS, DIA-NN integration |
| Compliance | 21 CFR Part 11, GLP/GMP ready |