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Key Features:
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The Shimadzu Nexera X2 UHPLC System is a next-generation, high-speed, high-resolution chromatography platform engineered for advanced analytical and bioanalytical applications.
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With a pressure tolerance up to 130 MPa (18,850 psi), the Nexera X2 supports sub-2 µm and core-shell particle columns, ensuring ultra-high resolution and rapid separations.
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Offers binary, ternary, and quaternary gradient options, giving labs flexibility for method development and complex solvent systems.
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Incorporates ultra-fast autosampler with high-precision injections, ultra-low carryover (<0.0015%), and temperature control for sensitive biological samples.
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Column oven with dual-heating technology (forced air circulation and precise column heating) for temperature stability and reproducibility.
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Fully compatible with advanced detectors: PDA, fluorescence, RI, ELSD, and seamlessly couples with high-resolution and triple quadrupole mass spectrometers.
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Controlled through Shimadzu LabSolutions software with full GLP/GMP compliance and 21 CFR Part 11 data integrity support.
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Modular, scalable design allows custom configuration for analytical, bioanalytical, and MS-coupled workflows.
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Applications:
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Pharmaceutical & Biopharmaceutical: Drug discovery, method development, impurity profiling, stability testing, QC in GMP-regulated environments.
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Proteomics & Metabolomics: High-throughput separation of peptides, proteins, metabolites, amino acids, and complex biomolecules.
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Food & Nutraceuticals: Analysis of vitamins, preservatives, aflatoxins, natural products, and nutritional profiling.
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Environmental Testing: Trace-level detection of pesticides, herbicides, and organic pollutants.
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Clinical & Biomedical Research: Bioanalysis of drugs and metabolites, biomarker assays, pharmacokinetics, hormone testing.
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Forensic & Toxicology: Screening of drugs of abuse, toxins, and trace contaminants.
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Industrial & Specialty Chemicals: Polymer characterization, purity testing, and process monitoring.
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Specifications:
| Parameter | Specification |
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| System Type | Modular UHPLC system |
| Pressure Rating | Up to 130 MPa (18,850 psi) |
| Flow Rate Range | 0.0001–5.0 mL/min (precise flow control) |
| Pump Options | Binary, ternary, and quaternary gradient solvent delivery |
| Gradient Accuracy | ±0.1% or better |
| Autosampler | 0.1–100 µL injection range, cooling/heating capability (4–40 °C), ultra-low carryover <0.0015% |
| Column Oven | Ambient +4 °C to 90 °C, dual heating system, column-switching capability |
| Detector Options | UV-Vis, PDA, fluorescence, RID, ELSD, MS coupling |
| Software | Shimadzu LabSolutions CDS (GLP/GMP and 21 CFR Part 11 compliant) |
| Carryover | <0.0015% (ultra-low) |
| Sample Throughput | Ultra-fast analysis cycles, high sample capacity |
| Dimensions | Modular, stackable design to save bench space |