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Shimadzu Nexera XS UHPLC System
  • Key Features:

    • The Shimadzu Nexera XS UHPLC System is a high-sensitivity, high-resolution ultra-high-performance liquid chromatography platform, optimized for bioanalysis, proteomics, metabolomics, and pharmaceutical research.

    • Engineered for ultra-high resolution separations, with a maximum pressure rating of 130 MPa (18,850 psi), supporting sub-2 µm and core-shell particle columns.

    • Features enhanced detection sensitivity, making it particularly suited for trace-level and low-abundance analytes in complex biological matrices.

    • Autosampler with high-precision injection and minimal carryover (<0.001%), combined with cooling and heating options for temperature-sensitive biomolecules.

    • Column oven with advanced dual-heating technology provides highly stable and reproducible temperature control.

    • Compatible with a full range of detectors: PDA, fluorescence, RID, ELSD, and seamlessly couples with mass spectrometry platforms (triple quadrupole, Q-TOF, HRMS).

    • Integrated with Shimadzu LabSolutions software, enabling full GLP/GMP compliance and 21 CFR Part 11 support for regulated environments.

    • Modular, compact, and scalable architecture that can be customized for stand-alone UHPLC analysis or LC-MS/MS workflows.

  • Applications:

    • Pharmaceutical & Biopharmaceuticals: Bioanalytical assays, impurity profiling, stability testing, QC in GMP labs, biosimilar analysis.

    • Proteomics & Metabolomics: Separation and quantification of peptides, proteins, amino acids, lipids, metabolites, and complex biomolecule mixtures.

    • Food & Nutraceuticals: High-resolution testing of vitamins, additives, preservatives, contaminants, and bioactive compounds.

    • Environmental Testing: Trace-level detection of pesticides, endocrine disruptors, persistent organic pollutants, and water contaminants.

    • Clinical & Biomedical Research: Quantification of biomarkers, hormones, therapeutic drugs, and diagnostic targets.

    • Forensic & Toxicology: Screening of drugs, metabolites, toxins, and controlled substances at ultra-low concentrations.

    • Industrial Chemistry & Specialty Applications: Polymer analysis, specialty chemicals purity testing, fine chemical characterization.

  • Specifications:

Parameter Specification
System Type Modular UHPLC platform
Pressure Rating Up to 130 MPa (18,850 psi)
Flow Rate Range 0.0001–5.0 mL/min (high-precision control)
Pump Options Binary, ternary, and quaternary gradient solvent delivery
Gradient Accuracy ±0.1% or better
Autosampler Injection range 0.1–100 µL, cooled/heated (4–40 °C), carryover <0.001%
Column Oven Ambient +4 °C to 90 °C, dual-heating technology, supports column switching
Detector Options UV-Vis, PDA, RID, fluorescence, ELSD, MS integration (Q-TOF, Triple Quad, HRMS)
Software Shimadzu LabSolutions CDS (GLP/GMP and 21 CFR Part 11 compliant)
Carryover <0.001% (ultra-low carryover)
Throughput Optimized for sensitive assays with reproducibility across large sample sets
AI/Automation Smart startup/shutdown routines, self-diagnostics, automated maintenance alerts
Dimensions Modular, space-saving stackable design


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