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Key Features:
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The Shimadzu Nexera XS UHPLC System is a high-sensitivity, high-resolution ultra-high-performance liquid chromatography platform, optimized for bioanalysis, proteomics, metabolomics, and pharmaceutical research.
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Engineered for ultra-high resolution separations, with a maximum pressure rating of 130 MPa (18,850 psi), supporting sub-2 µm and core-shell particle columns.
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Features enhanced detection sensitivity, making it particularly suited for trace-level and low-abundance analytes in complex biological matrices.
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Autosampler with high-precision injection and minimal carryover (<0.001%), combined with cooling and heating options for temperature-sensitive biomolecules.
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Column oven with advanced dual-heating technology provides highly stable and reproducible temperature control.
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Compatible with a full range of detectors: PDA, fluorescence, RID, ELSD, and seamlessly couples with mass spectrometry platforms (triple quadrupole, Q-TOF, HRMS).
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Integrated with Shimadzu LabSolutions software, enabling full GLP/GMP compliance and 21 CFR Part 11 support for regulated environments.
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Modular, compact, and scalable architecture that can be customized for stand-alone UHPLC analysis or LC-MS/MS workflows.
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Applications:
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Pharmaceutical & Biopharmaceuticals: Bioanalytical assays, impurity profiling, stability testing, QC in GMP labs, biosimilar analysis.
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Proteomics & Metabolomics: Separation and quantification of peptides, proteins, amino acids, lipids, metabolites, and complex biomolecule mixtures.
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Food & Nutraceuticals: High-resolution testing of vitamins, additives, preservatives, contaminants, and bioactive compounds.
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Environmental Testing: Trace-level detection of pesticides, endocrine disruptors, persistent organic pollutants, and water contaminants.
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Clinical & Biomedical Research: Quantification of biomarkers, hormones, therapeutic drugs, and diagnostic targets.
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Forensic & Toxicology: Screening of drugs, metabolites, toxins, and controlled substances at ultra-low concentrations.
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Industrial Chemistry & Specialty Applications: Polymer analysis, specialty chemicals purity testing, fine chemical characterization.
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Specifications:
| Parameter | Specification |
|---|---|
| System Type | Modular UHPLC platform |
| Pressure Rating | Up to 130 MPa (18,850 psi) |
| Flow Rate Range | 0.0001–5.0 mL/min (high-precision control) |
| Pump Options | Binary, ternary, and quaternary gradient solvent delivery |
| Gradient Accuracy | ±0.1% or better |
| Autosampler | Injection range 0.1–100 µL, cooled/heated (4–40 °C), carryover <0.001% |
| Column Oven | Ambient +4 °C to 90 °C, dual-heating technology, supports column switching |
| Detector Options | UV-Vis, PDA, RID, fluorescence, ELSD, MS integration (Q-TOF, Triple Quad, HRMS) |
| Software | Shimadzu LabSolutions CDS (GLP/GMP and 21 CFR Part 11 compliant) |
| Carryover | <0.001% (ultra-low carryover) |
| Throughput | Optimized for sensitive assays with reproducibility across large sample sets |
| AI/Automation | Smart startup/shutdown routines, self-diagnostics, automated maintenance alerts |
| Dimensions | Modular, space-saving stackable design |