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Waters ACQUITY Arc UHPLC System with Waters 2489 UV/Vis Detector  versatile quaternary UHPLC platform bridging HPLC and UHPLC methods, ideal for pharmaceutical, food, environmental, clinical, and research laboratories.
  • Key Features:

    • The Waters ACQUITY Arc UHPLC is a flexible quaternary gradient system designed to seamlessly bridge HPLC and UHPLC methods, enabling easy method transfer without revalidation challenges.

    • Equipped with the Waters 2489 Dual Wavelength UV/Vis Detector, offering highly sensitive and stable detection in the 190–700 nm range.

    • Operates at pressures up to 9,500 psi (≈ 660 bar), suitable for both HPLC and UHPLC workflows with 2.5–5 µm and sub-2 µm particle columns.

    • Arc Multi-flow path technology allows users to switch between HPLC and UHPLC modes for optimal resolution and throughput.

    • Quaternary solvent blending supports complex gradients and diverse solvent compatibility.

    • Integrated column heater/cooler ensures robust thermal stability and reproducibility.

    • Autosampler with precise injection volumes and low carryover for accurate, repeatable analyses.

    • Fully integrated with Waters Empower CDS for control, reporting, data integrity, and regulatory compliance.

    • Compliant with GLP/GMP and 21 CFR Part 11, ensuring suitability for regulated labs.

  • Applications:

    • Pharmaceutical & Biopharmaceutical: QC, assay, impurity profiling, dissolution testing, stability studies, method transfer from HPLC to UHPLC.

    • Food & Beverage: Detection of vitamins, sweeteners, additives, contaminants, and preservatives.

    • Environmental: Pesticide, herbicide, and pharmaceutical residue monitoring.

    • Clinical & Forensic: Drug analysis, toxicology screening, therapeutic drug monitoring.

    • Chemical Industry: Routine QC of intermediates, polymers, surfactants, and fine chemicals.

    • Academia & Training Labs: Method development, HPLC-to-UHPLC training, versatile teaching instrument.

  • Specifications:

Parameter Specification
System Type Ultra-High Performance Liquid Chromatography (UHPLC)
Pump Quaternary solvent delivery, flow range 0.001–10 mL/min
Max Pressure Up to 9,500 psi (≈ 660 bar)
Autosampler High-precision, programmable injections, typical volume 1–100 µL
Column Oven Temperature control from ambient +4 °C to 65 °C
Detector (2489 UV/Vis) Dual-wavelength UV/Vis, 190–700 nm, high sensitivity, stable baselines
Resolution Compatible with both HPLC (2.5–5 µm) and UHPLC (<2 µm) column technologies
Software Waters Empower Chromatography Data System (CDS)
Compliance GLP/GMP, 21 CFR Part 11 compliant


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