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Key Features:
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The Waters ACQUITY I-Class UPLC is the highest-performance ACQUITY platform, designed for ultra-fast, high-resolution, and ultra-sensitive separations.
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Utilizes a binary solvent delivery system with low system dispersion, maximizing sensitivity and resolution for sub-2 μm and sub-2 minute runs.
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Supports operation at pressures up to 18,000 psi (1240 bar), enabling advanced separations with the latest column technologies.
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Delivers improved gradient precision and minimized delay volume, critical for UHPLC method transfer and micro/analytical-scale workflows.
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Autosampler with enhanced precision supports injection volumes as low as 50 nL, optimized for micro-flow and analytical flow applications.
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Integrated column heater/cooler provides consistent temperature control for reproducibility.
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Compatible with Waters’ advanced detectors: PDA, TUV, FLR, QDa Mass Detector, or coupled to high-resolution MS systems (e.g., Xevo, SYNAPT, Vion).
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Fully integrated with Waters Empower CDS for complete data acquisition, reporting, and regulatory compliance.
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Designed for 21 CFR Part 11, GLP, GMP compliance with full audit trail features.
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Applications:
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Pharmaceutical & Biopharma: Impurity profiling, peptide and protein analysis, chiral separations, bioequivalence studies, stability and QC assays.
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Omics Research: Metabolomics, lipidomics, proteomics, biomarker discovery requiring high sensitivity and resolution.
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Clinical Research: Bioanalytical studies with trace-level quantification.
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Food & Beverage: Detection of contaminants, mycotoxins, pesticides, vitamins, and preservatives.
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Environmental Testing: Ultra-trace detection of pollutants, pharmaceuticals, pesticides, and emerging contaminants.
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Forensic/Toxicology: High-speed drug screening, toxicant analysis, doping control.
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Chemical & Material Sciences: Advanced QC testing of fine chemicals, polymers, catalysts, and additives.
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Academia/Research: Leading-edge UHPLC separations for advanced life sciences research.
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Specifications:
| Parameter | Specification |
|---|---|
| System Type | Ultra-High Performance Liquid Chromatography (UHPLC) |
| Pump | Binary solvent delivery, flow rate 0.001–2 mL/min |
| Max Pressure | Up to 18,000 psi (1240 bar) |
| Autosampler | High-precision autosampler, injection range 50 nL–10 µL, ultra-low carryover |
| Column Oven | Column heater/cooler, temperature range ambient +4 °C to 90 °C |
| Dispersion Volume | < 20 µL, optimized for ultra-fast separations |
| Detectors (options) | PDA (190–800 nm), TUV (UV/Vis), FLR (Fluorescence), QDa (Mass Detector) |
| Resolution | Optimized for sub-2 µm particle columns and fast gradient methods |
| Software | Waters Empower Chromatography Data System (CDS) |
| Compliance | GLP/GMP, 21 CFR Part 11 compliant |