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AB Sciex 4500 Triple Quadrupole LC-MS/MS high-performance quantitative LC-MS/MS system for pharmaceutical, clinical, food safety, and environmental applications with robust sensitivity and throughput.

Key Features:

  • Proven Triple Quadrupole Design: Successor to the industry-standard API 4000™ with enhanced robustness and sensitivity.

  • MRM Sensitivity: Capable of precise, reproducible targeted quantitation with low limits of detection.

  • Fast Polarity Switching: <20 ms switching for workflows requiring both positive and negative ion monitoring.

  • Dynamic MRM (dMRM): Optimizes cycle time and dwell time automatically for complex multi-analyte assays.

  • Enhanced Ion Path: Improved ion optics and collision cell design for higher efficiency and signal-to-noise ratio.

  • Wide Linear Dynamic Range: Suitable for quantitation of both trace-level and abundant analytes.

  • Flexible Ion Sources: Compatible with Turbo V™ ion source, DuoSpray® source, and APCI for versatility across compound classes.

  • Robust Throughput: Engineered for high-throughput targeted workflows with minimal downtime.

  • 21 CFR Part 11 Ready: Full compliance for regulated labs.


Applications:

  • Pharmaceutical Research & QA/QC: Bioanalysis, PK/PD studies, and impurity profiling.

  • Food & Beverage Testing: Pesticides, mycotoxins, veterinary drug residues, and contaminants.

  • Environmental Analysis: Trace detection of pollutants and emerging contaminants in water, soil, and air.

  • Clinical & Forensic Research: Drug screening, toxicology, and therapeutic drug monitoring.

  • Biological Studies: Targeted proteomics and metabolomics with reproducible quantitative data.


Specifications (Table):

Parameter Specification
MS Type Triple Quadrupole LC-MS/MS
Mass Range m/z 5 – 2,000
Mass Resolution Unit resolution (0.7 Da FWHM)
Polarity Switching <20 ms
Dynamic Range Linear over 5–6 orders of magnitude
Acquisition Modes MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan
Ionization Sources Turbo V™, DuoSpray®, APCI
Scan Speed Up to 5,000 Da/sec
Collision Cell Q2 with LINAC® collision cell technology
Vacuum System Dual turbomolecular pumps
Software Analyst® Software, optional SCIEX OS compatibility
Compliance 21 CFR Part 11, GLP/GMP ready


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