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Key Features:
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Latest-Generation Q-TOF Platform: Designed for high-resolution, accurate-mass (HRAM) analysis with exceptional stability and reproducibility.
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Integrated 1290 Infinity III UHPLC: Provides ultrahigh chromatographic resolution with precision flow control for robust separations.
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High Mass Resolution: >60,000 FWHM for confident identification of small molecules in complex samples.
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Superior Mass Accuracy: <1 ppm with reference mass correction, ensuring precise compound identification.
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Fast Polarity Switching: <20 ms positive/negative switching for comprehensive small molecule profiling.
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Flexible Ionization Sources: Compatible with Agilent Jet Stream ESI, APCI, and multimode sources.
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Multiple Acquisition Modes: Full scan, AutoMS/MS, targeted MS/MS, DIA, and DDA for both discovery and targeted workflows.
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Dynamic Range & Sensitivity: 5–6 orders of magnitude dynamic range for trace-level detection alongside major components.
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High-Speed Acquisition: Up to 50 spectra/sec, supporting UHPLC workflows with sharp peak widths.
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Enhanced Small Molecule Workflows: Optimized for pharmaceuticals, food safety, environmental testing, and metabolomics.
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Integrated Software: Agilent MassHunter and molecular feature extraction tools for compound identification, library searching, and regulatory compliance.
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Regulatory Ready: 21 CFR Part 11 support for GLP/GMP environments.
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Scalable & Modular: Configurable with automation, high-throughput autosamplers, and laboratory informatics.
Applications:
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Pharmaceutical Development: Small molecule drug screening, metabolite identification, and impurity profiling.
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Metabolomics & Lipidomics: Untargeted and targeted workflows for biomarker discovery.
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Food Safety & Quality Control: Detection of pesticides, contaminants, adulterants, and authenticity testing.
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Environmental Analysis: Monitoring pollutants, pesticides, pharmaceuticals, and emerging contaminants.
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Forensics & Toxicology: Screening for drugs of abuse, toxins, and forensic unknowns.
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Clinical & Translational Research: Discovery of metabolic pathways and disease biomarkers.
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Academic Research: Comprehensive small molecule screening in chemistry and biology labs.
Specifications (Table):
| Parameter | Specification |
|---|---|
| LC/MS Platform | Agilent 1290 Infinity III UHPLC with Revident LC/Q-TOF |
| MS System Type | Quadrupole Time-of-Flight (Q-TOF) |
| Mass Range | m/z 20 – 20,000 |
| Resolving Power | >60,000 FWHM |
| Mass Accuracy | <1 ppm with reference mass correction |
| Ionization Modes | ESI with Jet Stream Technology, APCI, multimode ion sources |
| Polarity Switching | <20 ms |
| Acquisition Modes | Full scan, AutoMS/MS, DIA, DDA, targeted MS/MS |
| Acquisition Rate | Up to 50 spectra/sec |
| Dynamic Range | 5–6 orders of magnitude |
| Fragmentation | Collision-induced dissociation (CID) |
| Vacuum System | Turbo molecular pumps with differential pumping |
| Interface | Orthogonal spray ion source with ion optics |
| Autosampler | InfinityLab series autosamplers |
| Software | Agilent MassHunter, molecular feature extraction, compound databases |
| Compliance | 21 CFR Part 11 support, GLP/GMP ready |