Skip to product information
Agilent 6545XT AdvanceBio LC/Q-TOF high-resolution quadrupole time-of-flight LC-MS system optimized for biopharmaceutical analysis, proteomics, glycomics, oligonucleotides, and intact protein characterization.
  • Agilent 6545XT AdvanceBio LC/Q-TOF high-resolution quadrupole time-of-flight LC-MS system optimized for biopharmaceutical analysis, proteomics, glycomics, oligonucleotides, and intact protein characterization.
  • Agilent 6545XT AdvanceBio LC/Q-TOF high-resolution quadrupole time-of-flight LC-MS system optimized for biopharmaceutical analysis, proteomics, glycomics, oligonucleotides, and intact protein characterization.
Agilent Technologies 6545XT AdvanceBio LC/Q-TOF
$0.00

Key Features:

  • AdvanceBio-Optimized Design: Purpose-built for biopharmaceutical characterization, including intact proteins, oligonucleotides, glycans, and complex biologics.

  • High-Resolution Accurate Mass (HRAM): Resolving power >40,000 FWHM with sub-1 ppm mass accuracy using reference mass correction.

  • Native MS Capability: Supports native electrospray conditions for structural biology studies and intact protein complexes.

  • Extended Mass Range: Covers m/z 20–20,000 for peptides, intact proteins, oligos, and large biomolecules.

  • Enhanced Sensitivity: Detects trace-level analytes and impurities in complex biological matrices.

  • Ion Funnel & Orthogonal Spray Source: Improved ion transmission efficiency and reduced noise.

  • Flexible Ionization Sources: Compatible with ESI with Jet Stream Technology, APCI, and multimode sources.

  • Fast Polarity Switching: <20 ms switching between positive and negative ion modes.

  • Comprehensive Acquisition Modes: Full-scan MS, AutoMS/MS, data-dependent (DDA), and data-independent acquisition (DIA).

  • BioConfirm Software Integration: Provides automated workflows for intact protein and glycan characterization.

  • Scalable Platform: Can be paired with 1290 Infinity II Bio-Inert UHPLC for minimal sample interaction.

  • Regulatory Compliance: 21 CFR Part 11 support for GMP/GLP laboratories.

Applications:

  • Biopharmaceutical Characterization: Intact mass analysis of monoclonal antibodies (mAbs), biosimilars, and therapeutic proteins.

  • Proteomics Research: PTM identification, protein sequencing, and biomarker discovery.

  • Glycomics & Glycoproteomics: Structural elucidation of N- and O-linked glycans.

  • Oligonucleotide Analysis: Sequence verification and impurity profiling of therapeutic oligos.

  • Drug Development: Impurity identification, metabolite profiling, and stability studies.

  • Native MS Structural Biology: Preserves non-covalent interactions for conformational analysis of protein complexes.

  • Food & Environmental Testing: Analysis of complex biological samples for contaminants and trace analytes.

  • Forensic & Clinical Research: Advanced biomarker discovery, toxicology, and disease pathway studies.

Specifications (Table):

Parameter Specification
MS System Type Quadrupole Time-of-Flight (Q-TOF)
Mass Range m/z 20 – 20,000
Resolving Power >40,000 FWHM
Mass Accuracy <1 ppm with reference mass correction
Ionization Modes ESI with Jet Stream Technology, APCI, multimode source
Polarity Switching <20 ms
Acquisition Modes Full scan, AutoMS/MS, DDA, DIA, targeted MS/MS
Dynamic Range 5–6 orders of magnitude
Fragmentation High-efficiency collision-induced dissociation (CID)
Vacuum System Turbo molecular pumps with differential pumping
Interface Orthogonal spray ion source with ion funnel
Software Agilent MassHunter Workstation, BioConfirm suite
Compliance 21 CFR Part 11 support, GLP/GMP ready



You may also like