Skip to product information
SCIEX QTRAP 4500 LC-MS/MS with Shimadzu Nexera UHPLC hybrid triple quadrupole linear ion trap UHPLC-MS/MS system for high-sensitivity quantitation and structural elucidation in pharmaceutical, food safety, environmental, and clinical toxicology workflows.
  • SCIEX QTRAP 4500 LC-MS/MS with Shimadzu Nexera UHPLC hybrid triple quadrupole linear ion trap UHPLC-MS/MS system for high-sensitivity quantitation and structural elucidation in pharmaceutical, food safety, environmental, and clinical toxicology workflows.
  • SCIEX QTRAP 4500 LC-MS/MS with Shimadzu Nexera UHPLC hybrid triple quadrupole linear ion trap UHPLC-MS/MS system for high-sensitivity quantitation and structural elucidation in pharmaceutical, food safety, environmental, and clinical toxicology workflows.
SCIEX QTRAP 4500 LC-MS/MS with Shimadzu Nexera UHPLC
$0.00

Key Features:

  • Hybrid QTRAP Technology: Combines quantitative triple quadrupole MS with qualitative linear ion trap scanning, offering MRM sensitivity plus structural elucidation capabilities.

  • Shimadzu Nexera UHPLC Front-End: High-throughput ultra-high-performance liquid chromatography system providing fast gradients, high resolution, and exceptional retention time reproducibility.

  • High-Speed Quantitation: Up to 1000 MRM transitions per second with optimized dwell times for narrow UHPLC peaks.

  • Enhanced Product Ion (EPI) and MS³ Capability: Enables confirmatory analysis of unknowns, impurities, and metabolites.

  • Turbo V™ Source with ESI and APCI Options: Reliable ionization across diverse compound classes with minimal matrix effects.

  • Polarity Switching: <50 ms polarity switching, suitable for multi-class analysis in a single run.

  • Compact, Efficient Design: The QTRAP 4500 is a benchtop system that pairs seamlessly with Shimadzu Nexera UHPLC for workflow integration.

  • Software Ecosystem: SCIEX Analyst® and MultiQuant™ for MS, Shimadzu LabSolutions for chromatography, with full regulatory compliance.

  • Regulatory Compliance: 21 CFR Part 11 support and GLP/GMP compatibility.

Applications:

  • Pharmaceutical & Biopharma: Quantitative bioanalysis, DMPK, impurity profiling, metabolite identification.

  • Food Safety & Agriculture: Multi-residue pesticide testing, veterinary drugs, mycotoxins, and food additives.

  • Environmental Testing: Pharmaceuticals, endocrine disruptors, and pollutants in air, water, and soil samples.

  • Clinical & Forensic Toxicology: Drug screening, toxicology studies, biomarker quantitation.

  • Metabolomics & Lipidomics: Targeted pathway analysis with confirmatory structural information.

  • Academic & Translational Research: Multi-use platform for both research quantitation and structural elucidation.

Specifications (Table):

Parameter Specification
System Configuration SCIEX QTRAP 4500 LC-MS/MS + Shimadzu Nexera UHPLC
MS Type Hybrid Triple Quadrupole – Linear Ion Trap (QTRAP)
Mass Range m/z 5 – 2000
Resolution Unit resolution (0.7 Da FWHM)
Dynamic Range ~5 orders of magnitude
Ionization Modes Turbo V™ Source (ESI, APCI)
Polarity Switching <50 ms
Acquisition Modes MRM, SIM, EPI, MS³, Precursor Ion Scan, Neutral Loss Scan
MRM Transition Speed Up to 1000 transitions/sec
Sensitivity (LOQ) fg–pg level (compound dependent)
Collision Cell Q2 linear collision cell
Vacuum System Turbo molecular pump system
Front-End UHPLC Shimadzu Nexera UHPLC (binary/quaternary pumps, autosampler, column oven, UV/DAD detectors)
Autosampler Nexera X2/XT autosampler (low carryover, high precision injection)
Flow Range 0.001 – 10 mL/min (pump dependent)
Gradient Precision ≤ 0.1% RSD
Interface Turbo V ion source with orthogonal spray
Software SCIEX Analyst®, MultiQuant™ (MS); Shimadzu LabSolutions (UHPLC)
Compliance 21 CFR Part 11, GLP/GMP ready


You may also like