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Key Features:
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QTRAP Hybrid Technology: Integrates triple quadrupole quantitation with linear ion trap functionality for both targeted assays and structural elucidation.
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Shimadzu Nexera UHPLC Front-End: Ultra-fast, high-resolution separations with excellent retention time reproducibility and peak shape for demanding workflows.
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High Sensitivity & Dynamic Range: Detects analytes at fg–pg levels, with up to 5–6 orders of dynamic range.
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Fast MRM Quantitation: Up to 1000 MRM transitions/sec, optimized for narrow UHPLC peaks.
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Enhanced Product Ion (EPI) & MS³: Enables metabolite identification, impurity profiling, and confirmatory scans for unknowns.
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Turbo V™ Source with ESI/APCI: Flexible ionization with consistent performance across diverse compound classes.
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Polarity Switching: <50 ms, ensuring rapid positive/negative mode alternation within a single run.
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Compact Design: Bench-friendly, combining robust MS performance with Shimadzu’s modular UHPLC system.
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Regulatory-Ready Software: SCIEX Analyst® and MultiQuant™ with Shimadzu LabSolutions integration, supporting 21 CFR Part 11 and GLP/GMP compliance.
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Built for Productivity: Optimized for high-throughput, regulated workflows where speed, sensitivity, and reproducibility are critical.
Applications:
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Pharmaceutical & Biopharma: Bioanalysis, DMPK, drug metabolism, impurity profiling, metabolite ID.
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Food Safety & Agriculture: Multi-residue pesticide testing, mycotoxins, veterinary drugs, food additives.
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Environmental Testing: Monitoring pharmaceuticals, endocrine disruptors, pesticides, and pollutants in complex environmental matrices.
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Clinical & Forensic Toxicology: Drug screening, toxicology studies, forensic confirmation, biomarker quantitation.
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Metabolomics & Lipidomics: Targeted profiling with confirmatory EPI/MS³ scans.
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Translational & Academic Research: Suited for labs requiring hybrid workflows that combine quantitation and qualitative structural analysis.
Specifications (Table):
| Parameter | Specification |
|---|---|
| System Configuration | SCIEX QTRAP 5500 LC-MS/MS + Shimadzu Nexera UHPLC |
| MS Type | Hybrid Triple Quadrupole – Linear Ion Trap (QTRAP) |
| Mass Range | m/z 5 – 2000 |
| Resolution | Unit resolution (0.7 Da FWHM) |
| Dynamic Range | ~5–6 orders of magnitude |
| Ionization Modes | Turbo V™ Source (ESI, APCI) |
| Polarity Switching | <50 ms |
| Acquisition Modes | MRM, SIM, EPI, MS³, Precursor Ion, Neutral Loss Scan |
| MRM Transition Speed | Up to 1000 transitions/sec |
| Sensitivity (LOQ) | fg–pg level depending on analyte |
| Collision Cell | Q2 linear collision cell |
| Vacuum System | Turbo molecular pump system |
| Front-End UHPLC | Shimadzu Nexera UHPLC (binary/quaternary pumps, autosampler, column oven, UV/DAD detectors) |
| Autosampler | Shimadzu Nexera autosampler (low carryover, fast cycle time) |
| Flow Range | 0.001 – 10 mL/min (pump dependent) |
| Gradient Precision | ≤0.1% RSD |
| Interface | Turbo V ion source with orthogonal spray design |
| Software | SCIEX Analyst®, MultiQuant™ (MS); Shimadzu LabSolutions (UHPLC) |
| Compliance | 21 CFR Part 11, GLP/GMP ready |