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SCIEX QTRAP 5500 LC-MS/MS with Shimadzu Nexera UHPLC – ultra-fast hybrid triple quadrupole linear ion trap LC-MS/MS system for high-sensitivity quantitation and qualitative analysis in pharmaceutical, food safety, environmental, and clinical applications.

Key Features:

  • QTRAP Hybrid Technology: Integrates triple quadrupole quantitation with linear ion trap functionality for both targeted assays and structural elucidation.

  • Shimadzu Nexera UHPLC Front-End: Ultra-fast, high-resolution separations with excellent retention time reproducibility and peak shape for demanding workflows.

  • High Sensitivity & Dynamic Range: Detects analytes at fg–pg levels, with up to 5–6 orders of dynamic range.

  • Fast MRM Quantitation: Up to 1000 MRM transitions/sec, optimized for narrow UHPLC peaks.

  • Enhanced Product Ion (EPI) & MS³: Enables metabolite identification, impurity profiling, and confirmatory scans for unknowns.

  • Turbo V™ Source with ESI/APCI: Flexible ionization with consistent performance across diverse compound classes.

  • Polarity Switching: <50 ms, ensuring rapid positive/negative mode alternation within a single run.

  • Compact Design: Bench-friendly, combining robust MS performance with Shimadzu’s modular UHPLC system.

  • Regulatory-Ready Software: SCIEX Analyst® and MultiQuant™ with Shimadzu LabSolutions integration, supporting 21 CFR Part 11 and GLP/GMP compliance.

  • Built for Productivity: Optimized for high-throughput, regulated workflows where speed, sensitivity, and reproducibility are critical.


Applications:

  • Pharmaceutical & Biopharma: Bioanalysis, DMPK, drug metabolism, impurity profiling, metabolite ID.

  • Food Safety & Agriculture: Multi-residue pesticide testing, mycotoxins, veterinary drugs, food additives.

  • Environmental Testing: Monitoring pharmaceuticals, endocrine disruptors, pesticides, and pollutants in complex environmental matrices.

  • Clinical & Forensic Toxicology: Drug screening, toxicology studies, forensic confirmation, biomarker quantitation.

  • Metabolomics & Lipidomics: Targeted profiling with confirmatory EPI/MS³ scans.

  • Translational & Academic Research: Suited for labs requiring hybrid workflows that combine quantitation and qualitative structural analysis.


Specifications (Table):

Parameter Specification
System Configuration SCIEX QTRAP 5500 LC-MS/MS + Shimadzu Nexera UHPLC
MS Type Hybrid Triple Quadrupole – Linear Ion Trap (QTRAP)
Mass Range m/z 5 – 2000
Resolution Unit resolution (0.7 Da FWHM)
Dynamic Range ~5–6 orders of magnitude
Ionization Modes Turbo V™ Source (ESI, APCI)
Polarity Switching <50 ms
Acquisition Modes MRM, SIM, EPI, MS³, Precursor Ion, Neutral Loss Scan
MRM Transition Speed Up to 1000 transitions/sec
Sensitivity (LOQ) fg–pg level depending on analyte
Collision Cell Q2 linear collision cell
Vacuum System Turbo molecular pump system
Front-End UHPLC Shimadzu Nexera UHPLC (binary/quaternary pumps, autosampler, column oven, UV/DAD detectors)
Autosampler Shimadzu Nexera autosampler (low carryover, fast cycle time)
Flow Range 0.001 – 10 mL/min (pump dependent)
Gradient Precision ≤0.1% RSD
Interface Turbo V ion source with orthogonal spray design
Software SCIEX Analyst®, MultiQuant™ (MS); Shimadzu LabSolutions (UHPLC)
Compliance 21 CFR Part 11, GLP/GMP ready



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