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Key Features:
• Revolutionary dual analyzer design combining Orbitrap and Astral analyzers for unprecedented speed and resolution
• Acquisition speeds up to 200 Hz for ultra-deep proteome coverage in record time
• Resolving power exceeding 80,000 FWHM at m/z 200 with exceptional dynamic range
• Superior sensitivity enabling confident identification of >8,000 proteins in a single LC run
• Capable of single-cell proteomics with ultra-low sample amounts
• Compatible with advanced fragmentation methods (HCD, CID, ETD, EThcD)
• Seamless integration with nanoLC and UHPLC platforms for complex sample analysis
• Advanced data acquisition workflows optimized for DIA, DDA, and PRM experiments
• Software ecosystem: Xcalibur™, Proteome Discoverer™, Biopharma Finder™, and real-time search-enabled workflows
• Designed for robustness and throughput in high-demand omics and biopharma labs -
Applications:
• Large-scale quantitative proteomics and biomarker discovery
• Single-cell proteomics and low-abundance biomolecule detection
• High-throughput metabolomics and lipidomics
• Structural biology and post-translational modification (PTM) analysis
• Biopharmaceutical characterization (mAbs, ADCs, intact proteins)
• Multi-omics integration for systems biology research -
Specifications:
Specification Details MS Platform Thermo Scientific Orbitrap Astral MS System Type Hybrid Orbitrap–Astral LC-MS/MS Ionization Source Electrospray Ionization (ESI), nano-ESI Mass Analyzers Orbitrap + Astral Mass Resolution >80,000 FWHM at m/z 200 Acquisition Speed Up to 200 Hz Mass Accuracy <1 ppm with external calibration Fragmentation Methods HCD, CID, ETD, EThcD Polarity Modes Positive and negative switching Dynamic Range >6 orders of magnitude Sensitivity Sub-femtomole detection (single-cell compatible) Acquisition Modes DDA, DIA, PRM, real-time search (RTS) Software Thermo Xcalibur™, Proteome Discoverer™, BioPharma Finder™, Chromeleon™ Compliance 21 CFR Part 11 ready