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Key Features:
• Next-generation Tribrid architecture integrating quadrupole, Orbitrap, and linear ion trap analyzers
• Ultra-high resolution up to 1,000,000 FWHM at m/z 200 with sub-ppm mass accuracy
• Expanded fragmentation options: CID, HCD, ETD, EThcD, UVPD, and AI-driven acquisition strategies
• FAIMS Pro™ interface (optional) for enhanced selectivity and reduced chemical noise
• Intelligent data acquisition with real-time search (RTS) for increased proteomic depth
• SPS-MS³ and multinotch workflows for highly accurate TMT and iTRAQ quantitation
• Greater sensitivity and dynamic range compared to the Orbitrap Fusion Lumos
• Seamless integration with nanoLC, UHPLC, and advanced sample prep systems
• Comprehensive software ecosystem: Xcalibur™, Proteome Discoverer™, BioPharma Finder™, and Chromeleon™ -
Applications:
• Deep proteomics and post-translational modification (PTM) analysis
• Quantitative biomarker discovery using TMT, iTRAQ, and label-free workflows
• Metabolomics, lipidomics, and glycomics
• Biopharmaceutical development, intact mass analysis, and top-down proteomics
• Multi-omics research requiring ultra-high resolution and sensitivity
• Advanced structural biology and protein–ligand interaction studies -
Specifications:
Specification Details MS Platform Thermo Scientific Orbitrap Eclipse Tribrid MS System Type Hybrid Tribrid LC-MS/MS (Quadrupole, Orbitrap, Ion Trap) Ionization Source Electrospray Ionization (ESI), nano-ESI, UHPLC compatible Mass Analyzers Quadrupole, Orbitrap, Linear Ion Trap Mass Resolution Up to 1,000,000 FWHM at m/z 200 Mass Accuracy <1 ppm with external calibration Fragmentation Methods CID, HCD, ETD, EThcD, UVPD Polarity Modes Positive and negative ion switching Dynamic Range >6 orders of magnitude Sensitivity Sub-femtomole peptide/protein detection Acquisition Modes DDA, DIA, PRM, targeted MSn, real-time search (RTS) Optional Interface FAIMS Pro™ ion mobility interface Software Thermo Xcalibur™, Proteome Discoverer™, BioPharma Finder™, Chromeleon™ Compliance 21 CFR Part 11 compliant for regulated labs