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Thermo Scientific Orbitrap Eclipse Tribrid Mass Spectrometer Advanced high-resolution LC-MS/MS system for proteomics, metabolomics, and multi-omics research
  • Key Features:
    • Next-generation Tribrid architecture integrating quadrupole, Orbitrap, and linear ion trap analyzers
    • Ultra-high resolution up to 1,000,000 FWHM at m/z 200 with sub-ppm mass accuracy
    • Expanded fragmentation options: CID, HCD, ETD, EThcD, UVPD, and AI-driven acquisition strategies
    • FAIMS Pro™ interface (optional) for enhanced selectivity and reduced chemical noise
    • Intelligent data acquisition with real-time search (RTS) for increased proteomic depth
    • SPS-MS³ and multinotch workflows for highly accurate TMT and iTRAQ quantitation
    • Greater sensitivity and dynamic range compared to the Orbitrap Fusion Lumos
    • Seamless integration with nanoLC, UHPLC, and advanced sample prep systems
    • Comprehensive software ecosystem: Xcalibur™, Proteome Discoverer™, BioPharma Finder™, and Chromeleon™

  • Applications:
    • Deep proteomics and post-translational modification (PTM) analysis
    • Quantitative biomarker discovery using TMT, iTRAQ, and label-free workflows
    • Metabolomics, lipidomics, and glycomics
    • Biopharmaceutical development, intact mass analysis, and top-down proteomics
    • Multi-omics research requiring ultra-high resolution and sensitivity
    • Advanced structural biology and protein–ligand interaction studies

  • Specifications:

    Specification Details
    MS Platform Thermo Scientific Orbitrap Eclipse Tribrid
    MS System Type Hybrid Tribrid LC-MS/MS (Quadrupole, Orbitrap, Ion Trap)
    Ionization Source Electrospray Ionization (ESI), nano-ESI, UHPLC compatible
    Mass Analyzers Quadrupole, Orbitrap, Linear Ion Trap
    Mass Resolution Up to 1,000,000 FWHM at m/z 200
    Mass Accuracy <1 ppm with external calibration
    Fragmentation Methods CID, HCD, ETD, EThcD, UVPD
    Polarity Modes Positive and negative ion switching
    Dynamic Range >6 orders of magnitude
    Sensitivity Sub-femtomole peptide/protein detection
    Acquisition Modes DDA, DIA, PRM, targeted MSn, real-time search (RTS)
    Optional Interface FAIMS Pro™ ion mobility interface
    Software Thermo Xcalibur™, Proteome Discoverer™, BioPharma Finder™, Chromeleon™
    Compliance 21 CFR Part 11 compliant for regulated labs

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