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Thermo Scientific Orbitrap Exploris 480 LC-MS/MS with Vanquish UHPLC ultra-high-resolution mass spectrometer for quantitative proteomics, metabolomics, and pharmaceutical research
  • Key Features:

    • Orbitrap mass analyzer delivering ultra-high resolution up to 480,000 FWHM at m/z 200

    • Superior quantitative accuracy and dynamic range for complex biological and pharmaceutical samples

    • Vanquish UHPLC integration for high-throughput, reproducible separations with minimal carryover

    • Real-time Easy-IC calibration for sub-ppm mass accuracy across long analytical runs

    • Fast polarity switching and high scan speeds (>40 Hz) for comprehensive molecular profiling

    • Optimized ion optics and quadrupole isolation for high sensitivity and selectivity

    • Compliance-ready, scalable workflows for both discovery and targeted quantitation

  • Applications:

    • Proteomics: Quantitative proteomics, PTM analysis, deep proteome coverage

    • Pharmaceuticals: Drug discovery, pharmacokinetics, metabolite identification, impurity profiling

    • Metabolomics & Lipidomics: Comprehensive metabolic pathway analysis, biomarker discovery

    • Food Safety & Environmental Testing: Trace contaminant detection, pesticides, toxins, pollutants

    • Clinical & Translational Research: Disease biomarker identification, precision medicine

  • Specifications:

Specification Detail
LC/MS Platform Orbitrap Exploris 480 LC-MS/MS with Vanquish UHPLC
MS System Type High-Resolution Accurate Mass (HRAM) Orbitrap
Resolution Up to 480,000 FWHM at m/z 200
Mass Range m/z 40–6,000
Ionization Modes ESI (Electrospray Ionization), HESI (Heated Electrospray Ionization), APCI optional
Autosampler Thermo Scientific Vanquish UHPLC Autosampler
Acquisition Modes Full Scan, MS/MS (DDA, DIA), SIM, PRM, Targeted MSn, TMT-based workflows
Dynamic Range >6 orders of magnitude
Mass Accuracy <1 ppm with Easy-IC calibration
Scan Speed >40 Hz full MS at 15,000 resolution
Vacuum System Dual turbomolecular pumps with roughing pump
Interface HESI-II heated ESI source, optional APCI
Software Thermo Scientific Xcalibur, Proteome Discoverer, Chromeleon, TraceFinder
Compliance 21 CFR Part 11 compatible

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