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Key Features:
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Orbitrap mass analyzer delivering ultra-high resolution up to 480,000 FWHM at m/z 200
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Superior quantitative accuracy and dynamic range for complex biological and pharmaceutical samples
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Vanquish UHPLC integration for high-throughput, reproducible separations with minimal carryover
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Real-time Easy-IC calibration for sub-ppm mass accuracy across long analytical runs
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Fast polarity switching and high scan speeds (>40 Hz) for comprehensive molecular profiling
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Optimized ion optics and quadrupole isolation for high sensitivity and selectivity
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Compliance-ready, scalable workflows for both discovery and targeted quantitation
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Applications:
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Proteomics: Quantitative proteomics, PTM analysis, deep proteome coverage
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Pharmaceuticals: Drug discovery, pharmacokinetics, metabolite identification, impurity profiling
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Metabolomics & Lipidomics: Comprehensive metabolic pathway analysis, biomarker discovery
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Food Safety & Environmental Testing: Trace contaminant detection, pesticides, toxins, pollutants
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Clinical & Translational Research: Disease biomarker identification, precision medicine
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Specifications:
| Specification | Detail |
|---|---|
| LC/MS Platform | Orbitrap Exploris 480 LC-MS/MS with Vanquish UHPLC |
| MS System Type | High-Resolution Accurate Mass (HRAM) Orbitrap |
| Resolution | Up to 480,000 FWHM at m/z 200 |
| Mass Range | m/z 40–6,000 |
| Ionization Modes | ESI (Electrospray Ionization), HESI (Heated Electrospray Ionization), APCI optional |
| Autosampler | Thermo Scientific Vanquish UHPLC Autosampler |
| Acquisition Modes | Full Scan, MS/MS (DDA, DIA), SIM, PRM, Targeted MSn, TMT-based workflows |
| Dynamic Range | >6 orders of magnitude |
| Mass Accuracy | <1 ppm with Easy-IC calibration |
| Scan Speed | >40 Hz full MS at 15,000 resolution |
| Vacuum System | Dual turbomolecular pumps with roughing pump |
| Interface | HESI-II heated ESI source, optional APCI |
| Software | Thermo Scientific Xcalibur, Proteome Discoverer, Chromeleon, TraceFinder |
| Compliance | 21 CFR Part 11 compatible |