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Key Features:
• Enhanced Tribrid architecture integrating quadrupole, Orbitrap, and linear ion trap for advanced MS/MS workflows
• Ultra-high resolution up to 500,000 FWHM at m/z 200 with <1 ppm mass accuracy
• Expanded fragmentation options: CID, HCD, ETD, EThcD, UVPD (optional), and SPS-MS³ quantitation
• Higher sensitivity and dynamic range compared to the original Orbitrap Fusion
• Real-time library search and intelligent acquisition strategies for deeper proteomic coverage
• Optimized ion optics and ETD HD for higher PTM identification rates
• Full compatibility with nanoLC, capLC, and UHPLC front-end separations
• Powered by Xcalibur™, Proteome Discoverer™, and BioPharma Finder™ software -
Applications:
• In-depth proteomics and multi-omics research
• Post-translational modification (PTM) mapping and structural characterization
• Quantitative proteomics with TMT, iTRAQ, and label-free approaches
• Metabolomics and lipidomics requiring ultra-high resolution MS
• Biopharmaceutical development including intact mass and top-down proteomics
• Advanced academic, clinical, and industrial research requiring flexibility and sensitivity -
Specifications:
Specification Details MS Platform Thermo Scientific Orbitrap Fusion Lumos Tribrid MS System Type Hybrid Tribrid LC-MS/MS (Quadrupole, Orbitrap, Ion Trap) Ionization Source Electrospray Ionization (ESI), nano-ESI, UHPLC-compatible Mass Analyzers Quadrupole, Orbitrap, Linear Ion Trap Mass Resolution Up to 500,000 FWHM at m/z 200 Mass Accuracy <1 ppm with external calibration Fragmentation Methods CID, HCD, ETD, EThcD, UVPD (optional), SPS-MS³ Polarity Modes Positive and negative ion modes Dynamic Range >6 orders of magnitude Sensitivity Sub-femtomole detection for peptides/proteins Acquisition Modes DDA, DIA, PRM, targeted MSn Software Thermo Xcalibur™, Proteome Discoverer™, BioPharma Finder™ Compliance 21 CFR Part 11 compliant for regulated laboratories