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Key Features:
• Integrated LC-MS/MS platform combining the Orbitrap Fusion Lumos Tribrid with the UltiMate 3000 UHPLC system
• Tribrid architecture with Orbitrap, quadrupole, and linear ion trap for flexible MSn workflows
• UltiMate 3000 UHPLC provides ultra-high separation efficiency with low dispersion and high reproducibility
• Supports all major fragmentation techniques: CID, HCD, ETD, EThcD, and optional UVPD
• High-resolution accurate mass (HRAM) with up to 500,000 FWHM at m/z 200
• SPS-MS³ for precise isobaric quantitation in TMT and iTRAQ experiments
• Optimized for ultra-trace detection, PTM mapping, and complex omics workflows
• Full software integration with Xcalibur™, Chromeleon™, Proteome Discoverer™, and BioPharma Finder™ -
Applications:
• Comprehensive proteomics with UHPLC separation and Tribrid MS detection
• Post-translational modification (PTM) analysis with high sensitivity
• Quantitative biomarker discovery using TMT, iTRAQ, and label-free quantitation
• Multi-omics research including metabolomics and lipidomics
• Biopharmaceutical analysis – intact protein characterization, top-down proteomics, and glycoanalysis
• Clinical and translational research requiring robustness and reproducibility -
Specifications:
Specification Details MS Platform Thermo Orbitrap Fusion Lumos Tribrid MS System Type Hybrid Tribrid LC-MS/MS (Orbitrap, Quadrupole, Ion Trap) UHPLC System Thermo Scientific UltiMate 3000 UHPLC Ionization Source Electrospray Ionization (ESI), nano-ESI, capLC/UHPLC compatible Mass Analyzers Quadrupole, Orbitrap, Linear Ion Trap Mass Resolution Up to 500,000 FWHM at m/z 200 Mass Accuracy <1 ppm with external calibration Fragmentation Methods CID, HCD, ETD, EThcD, UVPD (optional), SPS-MS³ Polarity Modes Positive and negative ion modes Dynamic Range >6 orders of magnitude Sensitivity Sub-femtomole detection of peptides and proteins LC Flow Rates NanoLC to analytical flow (50 nL/min – 10 mL/min) LC Columns Compatible with a wide range of UHPLC columns Software Thermo Xcalibur™, Chromeleon™, Proteome Discoverer™, BioPharma Finder™ Compliance 21 CFR Part 11 compliant for regulated environments