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Key Features:
• Hybrid Quadrupole-Orbitrap HRAM platform with advanced ion optics and dual-pressure ion trap for speed and sensitivity
• Resolution up to 240,000 FWHM at m/z 200 with sub-ppm mass accuracy
• Faster scan speeds and higher sequencing rates than Q Exactive Plus, ideal for complex proteomes
• Enhanced HCD fragmentation for comprehensive peptide and metabolite characterization
• Integrated with Thermo Vanquish UHPLC for ultra-high performance separations and throughput
• Broad dynamic range with improved quantitation for label-free and multiplexed workflows
• Optimized for DIA and PRM methods to increase proteomic depth and reproducibility
• Streamlined workflow integration with Xcalibur™, Proteome Discoverer™, and TraceFinder™ software
• Robust design for continuous operation in high-throughput research and core facilities -
Applications:
• Proteomics: High-throughput protein identification, quantification, and PTM mapping
• Metabolomics & Lipidomics: Rapid profiling of complex biological mixtures
• Biopharma: Characterization of peptides, mAbs, and biosimilars
• Food Safety & Environmental Testing: Trace-level contaminant detection
• Systems Biology & Translational Research: Large-scale biomarker discovery -
Specifications:
Specification Details MS Platform Thermo Scientific Q Exactive HF Orbitrap MS System Type Hybrid Quadrupole-Orbitrap LC-MS/MS Coupled System Thermo Scientific Vanquish UHPLC Ionization Source Electrospray Ionization (ESI), nano-ESI Mass Analyzers Quadrupole + Orbitrap Mass Resolution Up to 240,000 FWHM at m/z 200 Mass Accuracy <1 ppm with external calibration Fragmentation Methods Higher-energy Collisional Dissociation (HCD) Polarity Modes Positive and negative switching Dynamic Range >5 orders of magnitude Sensitivity Sub-femtomole detection Acquisition Modes Full MS, MS/MS, PRM, DIA Software Thermo Xcalibur™, TraceFinder™, Proteome Discoverer™ Compliance 21 CFR Part 11 ready