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Key Features:
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Next-generation Triple Quadrupole LC-MS/MS delivering superior sensitivity and robustness
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Integrated Vanquish UHPLC for high-throughput and ultra-high-resolution chromatographic separations
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High-efficiency ion optics and collision cell technology ensure exceptional ion transmission and reproducibility
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Fast polarity switching (<5 ms) for comprehensive multi-analyte methods
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Wide linear dynamic range (>6 orders of magnitude) for both trace-level and high-concentration quantitation
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Improved signal-to-noise performance for challenging analytes in complex matrices
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TraceFinder software with compliance features for 21 CFR Part 11 environments
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Applications:
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Pharmaceuticals: Pharmacokinetics, bioequivalence, metabolite identification, impurity analysis
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Food Safety: Residue monitoring (pesticides, veterinary drugs, contaminants)
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Environmental Analysis: POPs, endocrine disruptors, emerging contaminants
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Clinical Research: Quantitative biomarker assays, therapeutic drug monitoring
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Forensics/Toxicology: Quantitative drug testing and toxicant screening
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Specifications:
| Specification | Detail |
|---|---|
| LC/MS Platform | TSQ Altis Triple Quadrupole LC-MS/MS with Vanquish UHPLC |
| MS System Type | Triple Quadrupole |
| Mass Range | m/z 10–2,000 |
| Ionization Modes | ESI (Electrospray Ionization), HESI (Heated Electrospray Ionization), APCI optional |
| Autosampler | Thermo Scientific Vanquish UHPLC Autosampler |
| Acquisition Modes | Full Scan, SIM, MRM (Multiple Reaction Monitoring), Quantitative MS/MS |
| Dynamic Range | >6 orders of magnitude |
| Mass Accuracy | Unit mass resolution in Q1 and Q3 quadrupoles |
| Scan Speed | >600 MRM transitions/sec |
| Vacuum System | Dual turbomolecular pumps with forepump |
| Interface | HESI-II heated electrospray source, optional APCI |
| Software | Thermo Scientific TraceFinder, Xcalibur, and Chromeleon software |
| Compliance | 21 CFR Part 11 compatible |