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Waters SYNAPT G2-S HDMS MALDI Q-TOF Mass Spectrometer High-definition MALDI-MS with ion mobility for proteomics, structural biology, and imaging applications
  • Key Features:
    • Advanced High Definition Mass Spectrometry (HDMS) platform integrating MALDI with Q-TOF and ion mobility separation (IMS)
    • TriWave™ ion mobility technology for separation of conformers, isomers, and complex biomolecular mixtures
    • Enhanced resolution and mass accuracy with high sensitivity for trace biomolecule detection
    • Flexible ionization: supports MALDI and optional electrospray ionization (ESI) sources
    • Suitable for high-resolution imaging mass spectrometry (MALDI-MSI) in tissue and biomarker analysis
    • Robust analytical performance for proteomics, metabolomics, and structural biology workflows
    • Powered by MassLynx™ and Driftscope™ software for integrated ion mobility visualization and interpretation

  • Applications:
    • Advanced proteomics and peptide sequencing
    • Imaging mass spectrometry for tissue mapping and biomarker studies
    • Structural biology – protein folding, conformations, and protein–ligand interactions
    • Lipidomics, metabolomics, and glycomics
    • Polymer, materials, and complex mixture analysis
    • Biopharmaceutical research and drug discovery

  • Specifications:

    Specification Details
    MS Platform Waters SYNAPT G2-S HDMS
    MS System Type MALDI Q-TOF with Ion Mobility (HDMS)
    Ionization Source Matrix-Assisted Laser Desorption/Ionization (MALDI); optional ESI
    Mass Analyzer Quadrupole – Orthogonal Acceleration Time-of-Flight (oa-TOF)
    Ion Mobility TriWave™ High-Definition Ion Mobility Separation
    Mass Resolution >25,000 FWHM (enhanced Q-TOF performance)
    Mass Accuracy <3 ppm with lock mass
    Polarity Modes Positive and negative ion modes
    Sensitivity High sensitivity for low-abundance biomolecules
    Imaging Capability MALDI-MSI with high spatial definition
    Software Waters MassLynx™, Driftscope™, and HDMS-specific data processing
    Compliance 21 CFR Part 11 compatible for regulated laboratories

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