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Key Features:
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Hybrid Q-TOF architecture combining quadrupole precursor selection with high-resolution TOF analysis
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Integrated ACQUITY UPLC system provides ultra-high chromatographic resolution and reproducibility
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ion mobility separation (IMS) option for enhanced peak capacity and separation of isobaric species
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High-resolution, accurate-mass capability (up to 40,000 FWHM) for confident molecular characterization
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MSE data acquisition technology enables simultaneous qualitative and quantitative analysis
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Wide dynamic range for trace detection alongside high-abundance analytes
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UNIFI scientific information system for streamlined workflows, data integration, and compliance support
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Applications:
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Proteomics: Deep proteome coverage, post-translational modification analysis
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Metabolomics: Biomarker discovery, metabolic profiling, flux analysis
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Pharmaceuticals: Drug metabolism studies, impurity analysis, structural elucidation
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Biopharmaceuticals: Intact protein and glycan characterization
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Environmental Testing: Identification of contaminants and unknowns in complex samples
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Food Safety: Screening for adulterants, residues, and authenticity verification
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Specifications:
| Specification | Detail |
|---|---|
| LC/MS Platform | SYNAPT G2-Si Q-TOF LC-MS/MS with ACQUITY UPLC |
| MS System Type | Quadrupole – Time-of-Flight (Q-TOF) Hybrid |
| Mass Range | m/z 20–100,000 |
| Resolution | Up to 40,000 FWHM |
| Ionization Modes | ESI, nanoESI, APCI, APPI optional |
| Autosampler | ACQUITY UPLC autosampler with temperature control |
| Acquisition Modes | MS, MS/MS, MSE (data-independent acquisition), HDMSE with ion mobility |
| Dynamic Range | >5 orders of magnitude |
| Mass Accuracy | <1 ppm with lock-mass calibration |
| Vacuum System | Multi-stage turbomolecular pumping |
| Interface | Z-Spray ion source, nanoLockSpray technology |
| Software | Waters UNIFI, MassLynx, Progenesis QI |
| Compliance | 21 CFR Part 11 compatible |