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Waters SYNAPT G2-Si Q-TOF LC-MS/MS with ACQUITY UPLC high-resolution hybrid quadrupole time-of-flight mass spectrometry system for proteomics, metabolomics, pharmaceutical, and biopharmaceutical applications
  • Key Features:

    • Hybrid Q-TOF architecture combining quadrupole precursor selection with high-resolution TOF analysis

    • Integrated ACQUITY UPLC system provides ultra-high chromatographic resolution and reproducibility

    • ion mobility separation (IMS) option for enhanced peak capacity and separation of isobaric species

    • High-resolution, accurate-mass capability (up to 40,000 FWHM) for confident molecular characterization

    • MSE data acquisition technology enables simultaneous qualitative and quantitative analysis

    • Wide dynamic range for trace detection alongside high-abundance analytes

    • UNIFI scientific information system for streamlined workflows, data integration, and compliance support

  • Applications:

    • Proteomics: Deep proteome coverage, post-translational modification analysis

    • Metabolomics: Biomarker discovery, metabolic profiling, flux analysis

    • Pharmaceuticals: Drug metabolism studies, impurity analysis, structural elucidation

    • Biopharmaceuticals: Intact protein and glycan characterization

    • Environmental Testing: Identification of contaminants and unknowns in complex samples

    • Food Safety: Screening for adulterants, residues, and authenticity verification

  • Specifications:

Specification Detail
LC/MS Platform SYNAPT G2-Si Q-TOF LC-MS/MS with ACQUITY UPLC
MS System Type Quadrupole – Time-of-Flight (Q-TOF) Hybrid
Mass Range m/z 20–100,000
Resolution Up to 40,000 FWHM
Ionization Modes ESI, nanoESI, APCI, APPI optional
Autosampler ACQUITY UPLC autosampler with temperature control
Acquisition Modes MS, MS/MS, MSE (data-independent acquisition), HDMSE with ion mobility
Dynamic Range >5 orders of magnitude
Mass Accuracy <1 ppm with lock-mass calibration
Vacuum System Multi-stage turbomolecular pumping
Interface Z-Spray ion source, nanoLockSpray technology
Software Waters UNIFI, MassLynx, Progenesis QI
Compliance 21 CFR Part 11 compatible

 

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