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Key Features:
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Integrated LC-MS Solution: Combines the robust quantitation power of the AB Sciex 4500 Triple Quad with the precision and throughput of the Agilent 1290 Infinity UHPLC.
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Superior Chromatographic Resolution: Ultra-high-pressure UHPLC delivers sharper peaks and faster separations.
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High-Sensitivity MRM Quantitation: Capable of detecting trace analytes with reproducible quantitative accuracy.
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Fast Polarity Switching: <20 ms for workflows requiring both positive and negative ion transitions.
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Dynamic MRM (dMRM): Automatically optimizes dwell and cycle times for large multi-analyte panels.
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Versatile Ion Sources: Compatible with Turbo V™ ion source, DuoSpray®, and APCI.
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Advanced Collision Cell: LINAC® collision cell technology for reduced crosstalk and enhanced signal.
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Wide Dynamic Range: Accurately quantifies both trace-level and high-abundance compounds.
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Regulatory Compliance: Supports 21 CFR Part 11 for GLP/GMP-regulated environments.
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Optimized for Routine High-Throughput Labs: Rugged design and low maintenance requirements for continuous operation.
Applications:
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Pharmaceutical R&D and QC: Drug metabolism, pharmacokinetics, bioequivalence studies, impurity analysis.
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Food & Beverage Safety: Monitoring pesticides, veterinary residues, mycotoxins, and other contaminants.
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Environmental Testing: Quantification of pollutants, trace organics, and emerging contaminants.
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Clinical & Forensic Analysis: Therapeutic drug monitoring, toxicology, and forensic screening.
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Biological Research: Targeted proteomics and metabolomics requiring fast UHPLC separation and precise MS quantitation.
Specifications (Table):
Parameter | Specification |
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MS Type | Triple Quadrupole LC-MS/MS |
Mass Range | m/z 5 – 2,000 |
Mass Resolution | Unit resolution (0.7 Da FWHM) |
Polarity Switching | <20 ms |
Dynamic Range | 5–6 orders of magnitude |
Scan Speed | Up to 5,000 Da/sec |
Acquisition Modes | MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan |
Ionization Sources | Turbo V™, DuoSpray®, APCI |
UHPLC System | Agilent 1290 Infinity UHPLC |
UHPLC Pressure | Up to 1,200 bar |
UHPLC Flow Rate Range | 0.001 – 5.0 mL/min |
UHPLC Column Heating | 10 – 100 °C |
Autosampler | Integrated Agilent 1290 Infinity with low carryover |
Collision Cell | LINAC® collision cell technology |
Vacuum System | Dual turbomolecular pumps |
Software | Analyst® Software (MS), Agilent OpenLab CDS or ChemStation (UHPLC) |
Compliance | 21 CFR Part 11, GLP/GMP ready |