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AB SCIEX 5500 QTRAP LC-MS/MS hybrid triple quadrupole linear ion trap system for ultra-sensitive quantitation and qualitative analysis in pharmaceutical, food safety, clinical toxicology, and environmental applications.

Key Features:

  • Hybrid QTRAP Architecture: Combines triple quadrupole MRM quantitation with linear ion trap scanning, enabling both targeted assays and qualitative workflows.

  • High Sensitivity: Significantly improved signal-to-noise ratio over the 4500 QTRAP, designed for fg–pg level detection in complex matrices.

  • High-Speed Quantitation: Handles up to 1000 MRM transitions/sec with optimized dwell times, suited for UHPLC separations.

  • Enhanced Product Ion (EPI) and MS³: Enables structural elucidation, impurity profiling, and metabolite identification.

  • Polarity Switching: Ultra-fast (<50 ms) switching between positive and negative ionization modes.

  • Turbo V™ Source: Robust and flexible with interchangeable ESI and APCI probes, supporting a wide compound range.

  • Dynamic Range: Broad quantitation range (5–6 orders of magnitude) for trace-level and high-concentration compounds.

  • Compact, Robust Design: Engineered for demanding analytical labs with high-throughput workflows.

  • Regulatory Compliance: Full support for FDA 21 CFR Part 11, GLP/GMP readiness, and validated workflows.

  • Software Ecosystem: SCIEX Analyst®, MultiQuant™, and supporting bioanalytical data solutions.


Applications:

  • Pharmaceutical & Biopharma: Quantitative bioanalysis, DMPK studies, pharmacokinetics, metabolite ID, impurity testing.

  • Food Safety & Agriculture: Detection of pesticide residues, mycotoxins, veterinary drugs, and contaminants in food products.

  • Environmental Testing: Monitoring pharmaceuticals, endocrine disruptors, and trace organic pollutants in environmental matrices.

  • Clinical & Forensic Toxicology: Drug screening, toxicology testing, clinical biomarker quantitation.

  • Metabolomics & Lipidomics: Targeted metabolite profiling with confirmatory structural analysis.

  • Academic & Translational Research: Supports hybrid workflows combining MRM quantitation with qualitative confirmation.


Specifications (Table):

Parameter Specification
System Configuration AB SCIEX 5500 QTRAP LC-MS/MS
MS Type Hybrid Triple Quadrupole – Linear Ion Trap (QTRAP)
Mass Range m/z 5 – 2000
Resolution Unit resolution (0.7 Da FWHM)
Dynamic Range ~5–6 orders of magnitude
Ionization Modes Turbo V™ Source (ESI, APCI)
Polarity Switching <50 ms
Acquisition Modes MRM, SIM, EPI, MS³, Precursor Ion Scan, Neutral Loss Scan
MRM Transition Speed Up to 1000 transitions/sec
Sensitivity (LOQ) fg–pg level depending on analyte
Collision Cell Q2 linear collision cell
Vacuum System Turbo molecular pumping system
Front-End Compatibility Works with most UHPLC/HPLC systems (Agilent, Shimadzu, Waters, Thermo)
Autosampler UHPLC/HPLC autosamplers compatible
Interface Turbo V ion source with orthogonal spray
Software SCIEX Analyst®, MultiQuant™
Compliance 21 CFR Part 11, GLP/GMP support



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