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Agilent 1290 Bio-inert LC with Revident LC/Q-TOF  advanced UHPLC high-resolution accurate mass spectrometry system for biopharmaceutical, proteomics, metabolomics, and pharmaceutical applications
  • Key Features:

    • Integrates the Agilent 1290 Infinity II Bio-inert LC with the Revident LC/Q-TOF, delivering next-generation high-resolution accurate mass (HRAM) capabilities.

    • Bio-inert flow path design prevents metal-analyte interactions, ideal for biopharmaceutical and biomolecule workflows.

    • Revident Q-TOF architecture provides enhanced mass accuracy, resolution, and sensitivity for both qualitative and quantitative studies.

    • Optimized for large biomolecules, proteins, intact mAbs, and complex omics samples.

    • Incorporates dual Agilent Jet Stream (AJS) technology for superior ionization efficiency.

    • Extended dynamic range supports low-level quantification and complex mixture analysis.

    • Seamlessly integrates with MassHunter BioConfirm and BioPharma software for automated characterization workflows.

  • Applications:

    • Biopharmaceutical Development: Monoclonal antibody characterization, intact protein analysis, glycosylation profiling.

    • Proteomics & Structural Biology: In-depth peptide mapping, post-translational modification analysis, and biomarker discovery.

    • Metabolomics & Lipidomics: Comprehensive profiling and quantification in biological systems.

    • Pharmaceutical R&D: Impurity analysis, drug metabolite identification, and stability studies.

    • Academic & Omics Research: High-resolution discovery workflows across proteomics, metabolomics, and systems biology.

  • Specifications:

Specification Detail
LC/MS Platform Agilent 1290 Infinity II Bio-inert LC with Revident LC/Q-TOF
MS System Type Quadrupole Time-of-Flight (Q-TOF), High-Resolution Accurate Mass (HRAM)
Mass Range m/z 20–40,000 (optimized for proteins and biomolecules)
Resolution >60,000 FWHM (HRAM)
Ionization Modes ESI, APCI, Dual AJS (Agilent Jet Stream)
Autosampler 1290 Bio-inert LC autosampler
Acquisition Modes MS, MS/MS, data-dependent (DDA), data-independent (DIA, All-Ions)
Dynamic Range >5 orders of magnitude
Mass Accuracy <1 ppm with reference mass correction
Vacuum System High-efficiency turbomolecular pump system
Interface Bio-inert AJS ESI source, optimized for labile biomolecules
Software Agilent MassHunter, BioConfirm, BioPharma
Compliance 21 CFR Part 11 compatible

 

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