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Key Features:
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Integrates the Agilent 1290 Infinity II Bio-inert LC with the Revident LC/Q-TOF, delivering next-generation high-resolution accurate mass (HRAM) capabilities.
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Bio-inert flow path design prevents metal-analyte interactions, ideal for biopharmaceutical and biomolecule workflows.
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Revident Q-TOF architecture provides enhanced mass accuracy, resolution, and sensitivity for both qualitative and quantitative studies.
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Optimized for large biomolecules, proteins, intact mAbs, and complex omics samples.
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Incorporates dual Agilent Jet Stream (AJS) technology for superior ionization efficiency.
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Extended dynamic range supports low-level quantification and complex mixture analysis.
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Seamlessly integrates with MassHunter BioConfirm and BioPharma software for automated characterization workflows.
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Applications:
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Biopharmaceutical Development: Monoclonal antibody characterization, intact protein analysis, glycosylation profiling.
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Proteomics & Structural Biology: In-depth peptide mapping, post-translational modification analysis, and biomarker discovery.
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Metabolomics & Lipidomics: Comprehensive profiling and quantification in biological systems.
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Pharmaceutical R&D: Impurity analysis, drug metabolite identification, and stability studies.
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Academic & Omics Research: High-resolution discovery workflows across proteomics, metabolomics, and systems biology.
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Specifications:
Specification | Detail |
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LC/MS Platform | Agilent 1290 Infinity II Bio-inert LC with Revident LC/Q-TOF |
MS System Type | Quadrupole Time-of-Flight (Q-TOF), High-Resolution Accurate Mass (HRAM) |
Mass Range | m/z 20–40,000 (optimized for proteins and biomolecules) |
Resolution | >60,000 FWHM (HRAM) |
Ionization Modes | ESI, APCI, Dual AJS (Agilent Jet Stream) |
Autosampler | 1290 Bio-inert LC autosampler |
Acquisition Modes | MS, MS/MS, data-dependent (DDA), data-independent (DIA, All-Ions) |
Dynamic Range | >5 orders of magnitude |
Mass Accuracy | <1 ppm with reference mass correction |
Vacuum System | High-efficiency turbomolecular pump system |
Interface | Bio-inert AJS ESI source, optimized for labile biomolecules |
Software | Agilent MassHunter, BioConfirm, BioPharma |
Compliance | 21 CFR Part 11 compatible |