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Agilent 1290 Infinity II UHPLC with 6546 Q-TOF LC/MS high-resolution accurate mass LC/MS system for proteomics, metabolomics, pharmaceutical, food safety, and environmental research applications, 1290 infinity ii uhplc, high-resolution accurate mass spectrometer, q-tof lc-ms system, metabolomics analysis, proteomics research, 
  • Key Features:

    • Combines the Agilent 1290 Infinity II UHPLC for ultra-high performance separations with the 6546 Q-TOF LC/MS for accurate mass, high-resolution detection.

    • High-resolution accurate mass (HRAM) capability ensures confident compound identification and quantification.

    • Enhanced mass accuracy and stability with Agilent’s True Peak positioning and reference mass correction.

    • Wide dynamic range with fast acquisition rates, ideal for untargeted and targeted workflows.

    • Advanced dual Agilent Jet Stream (AJS) technology for efficient ionization and maximum sensitivity.

    • Seamless integration with MassHunter software for qualitative and quantitative data analysis.

    • Suited for both discovery research and regulated applications requiring data integrity.

  • Applications:

    • Proteomics & Metabolomics: Biomarker discovery, protein and metabolite profiling, and systems biology.

    • Pharmaceutical Development: Impurity analysis, drug discovery, metabolite identification, and PK studies.

    • Environmental Testing: Screening of contaminants, pollutants, and emerging chemical threats.

    • Food Safety & Authenticity: Detection of adulterants, residues, and nutritional profiling.

    • Omics Research & Academia: Comprehensive small molecule and large molecule characterization.

  • Specifications:

Specification Detail
LC/MS Platform Agilent 1290 Infinity II UHPLC with 6546 Q-TOF LC/MS
MS System Type Quadrupole Time-of-Flight (Q-TOF), High-Resolution Accurate Mass (HRAM)
Mass Range m/z 20–40,000 (extended range for biomolecules)
Resolution >60,000 FWHM
Ionization Modes ESI, APCI, dual AJS (Agilent Jet Stream)
Autosampler 1290 Infinity II autosampler
Acquisition Modes MS, MS/MS (data-dependent and data-independent, including SWATH/All-Ions)
Dynamic Range >5 orders of magnitude
Mass Accuracy <1 ppm with reference mass correction
Vacuum System High-capacity turbomolecular pump system
Interface Dual AJS ESI source, interchangeable ion sources
Software Agilent MassHunter (Qualitative, Quantitative, Profinder, and VistaFlux)
Compliance 21 CFR Part 11 compatible

 

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