Agilent 6460 Triple Quadrupole LC/MS System with Agilent 1260 Infinity HPLC Mass Spectrometer
$85,000.00

Key Features

  • Jet Stream Enhanced Electrospray Ionization (AJS): Uses super-heated nitrogen to focus the spray, dramatically improving ion transmission and signal-to-noise performance.

  • Precise Quantitation via Dynamic & Triggered MRM: Supports dMRM and triggered MRM with fast polarity switching and dwell times as low as 1 ms.

  • Versatile Ion Source Support: Compatible with ESI, APCI, APPI, multimode (ESI + APCI), nanospray (HPLC-Chip), and Jet Stream-enabled ion sources.

  • Seamless Integration with 1260 Infinity HPLC: Fully controlled through MassHunter software, integrating LC method and MS acquisition seamlessly.

📌 Applications

  • Pharmaceutical & Clinical Research: Quantification of drugs, metabolites, and biomarkers at trace femtogram levels.

  • Environmental & Food Safety Testing: Detects trace pesticides, toxins, and contaminants in complex matrices.

  • Forensics & Bioanalysis: Suitable for toxicology screens, validation assays, and targeted metabolomics workflows.

⚙ Technical Specifications

Component Specifications
6460 Triple Quad MS - Mass Range: m/z 5–3,000
- Sensitivity (MRM): S/N > 10,000 (positive), > 3,000 (negative)
- Polarity Switching: 30 ms
- Scan Modes: MS, MS/MS, MRM, SIM, Neutral Loss/Gain, Precursor Scan
- Max Scan Rate: 12,500 Da/s
- Dynamic MRM: Up to 4,000 transitions/method
- Triggered MRM: Up to 10 confirmation transitions
- Mass Resolution: 0.7 Da (auto), 0.5 Da (manual)
- Mass Accuracy: ±0.1 Da (5–1,000), 0.01–0.02% (1,000–3,000)
- Mass Stability: <0.1 Da over 24 h
- Dynamic Range: > 6 × 10⁶
1260 Infinity HPLC - Binary Pump: 0.05–5 mL/min, up to 600 bar
- Autosampler: 0.1–100 µL precision injections, low carryover
- Column Compartment: 10 °C below ambient to 100 °C
- Modular flexibility: Compatible with both UHPLC and conventional HPLC methods

💡 Why Choose This System?

  • Ultra-High Sensitivity: Jet Stream technology delivers femtogram-level detection.

  • Integrated Workflows: 1260 HPLC + 6460 LC/MS combine for efficient, unified method control.

  • Versatility: Covers pharma, food safety, environmental, forensics, and metabolomics applications.

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