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Agilent 6460 Triple Quadrupole LC/MS/MS System, high-sensitivity liquid chromatography tandem mass spectrometer for pharmaceutical research, environmental testing, food safety analysis, forensic toxicology, and industrial chemical applications.
  • Agilent 6460 Triple Quadrupole LC/MS/MS System, high-sensitivity liquid chromatography tandem mass spectrometer for pharmaceutical research, environmental testing, food safety analysis, forensic toxicology, and industrial chemical applications.
  • Agilent 6460 Triple Quadrupole LC/MS/MS System, high-sensitivity liquid chromatography tandem mass spectrometer for pharmaceutical research, environmental testing, food safety analysis, forensic toxicology, and industrial chemical applications.
Agilent 6460 Triple Quadrupole LC/MS/MS System
$0.00

Key Features

  • Jet Stream Enhanced Electrospray Ionization (ESI): Boosts sensitivity using superheated nitrogen for focused ionization and higher S/N ratio.

  • Ultra-Sensitive Triple Quad Performance: Achieves femtogram-level detection, rapid scan speeds, and clean MS/MS transitions with Dynamic MRM and Triggered MRM.

  • Expanded Ionization Sources: Supports ESI, APCI, APPI, Multimode (ESI + APCI), and nanospray (via HPLC-Chip Cube interface).

  • Automated Instrument Optimization: Autotune enables fast and reliable optimization of ion optics and mass calibration.

šŸ“Œ Applications

  • Pharmaceutical & Clinical Research: Quantification of trace-level drugs, metabolites, and biomarkers with exceptional sensitivity.

  • Environmental & Food Safety Testing: Detects pesticides, toxins, and pollutants in complex matrices with high reproducibility.

  • Forensics & Bioanalysis: Ideal for toxicology screening, validation assays, and targeted metabolomics workflows.

āš™ Technical Specifications

Specification Details
Mass Range m/z 5ā€“3,000
Sensitivity (MRM) S/N > 10,000 @ 1 pg reserpine (positive); S/N > 3,000 @ 1 pg chloramphenicol (negative)
Polarity Switching 30 ms
Mass Resolution FWHM: 0.7 Da (Autotune), 0.5 Da (Manual)
Mass Accuracy Ā±0.1 Da (5ā€“1,000 m/z); 0.01ā€“0.02% (1,000ā€“3,000 m/z)
Mass Stability < 0.1 Da over 24 hours
Dynamic Range > 6 Ɨ 10ā¶
Scan Modes Supported MS scan, MS/MS product ion, MRM, SIM, Neutral loss/gain, Precursor ion scan
Max Scan Rate 12,500 Da/s
Dwell Time Minimum MRM dwell time: 1 ms
MRM Transitions 450 per segment; >13,500 per method
Dynamic MRM Transitions Up to 4,000 per method
Triggered MRM Up to 10 primary/secondary transitions
Collision Cell Clearance < 1 ms
Ion Sources Available ESI (standard), APCI, APPI, Multimode, nanospray (HPLC-Chip)
Autotune Automated optimization of ion optics and calibration
Software Integration Fully controlled via MassHunter; integrates with Agilent HPLC systems

šŸ’” Why Choose the Agilent 6460?

  • Industry-Leading Sensitivity ā€” Designed for trace-level quantitation.

  • High Throughput ā€” Dynamic MRM and fast polarity switching reduce cycle times.

  • Versatile Ionization Options ā€” Adapts to diverse workflows.

  • Regulatory Confidence ā€” Reliable mass accuracy and stability for critical analyses.

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