Pickup currently not available
Key Features:
-
Unparalleled Sensitivity: Sub-femtogram detection capability, ideal for low-abundance analytes.
-
Agilent iFunnel Technology: Enhances ion transmission efficiency, boosting signal intensity and sensitivity.
-
Fast Polarity Switching: <20 ms polarity switching for seamless dual-mode analysis.
-
Dynamic MRM (dMRM): Advanced acquisition mode for high-throughput targeted quantitation with improved reproducibility.
-
Ultra-Wide Dynamic Range: >5–6 orders of magnitude, ensuring accurate quantitation from trace to high-level compounds.
-
High MRM Speed: Capable of >500 transitions per second to support UHPLC peak widths.
-
Robust Collision Cell: LCID (linear collision-induced dissociation with axial acceleration) ensures high-quality, reproducible fragmentation.
-
Flexible Ionization: Compatible with Agilent Jet Stream ESI, APCI, and multimode ion sources.
-
Reliability & Uptime: Modular design, straightforward maintenance, and long-lasting performance in demanding labs.
-
Regulatory Compliance: Full 21 CFR Part 11 support with audit trails for GMP/GLP workflows.
-
MassHunter Software Suite: Simplifies data acquisition, quantitation, method optimization, and reporting.
Applications:
-
Pharmaceutical Development: Drug metabolism, pharmacokinetics, toxicology, bioanalysis, and impurity testing.
-
Biopharmaceuticals: Peptide/protein quantitation, stability testing, and process monitoring.
-
Food Safety: Quantitative screening of pesticides, veterinary drugs, mycotoxins, and contaminants.
-
Environmental Analysis: Monitoring trace pollutants, industrial chemicals, and pharmaceuticals in water/soil.
-
Clinical & Forensic Research: Targeted biomarker quantitation, drug testing, forensic toxicology workflows.
-
Metabolomics & Lipidomics: Quantitative profiling of metabolites and lipids.
-
High-Throughput Regulated Labs: Routine, validated workflows with robust performance and audit-ready documentation.
Specifications (Table):
| Parameter | Specification |
|---|---|
| System Configuration | Agilent 6490 Triple Quadrupole LC/MS |
| MS Type | Triple Quadrupole (LC-MS/MS) |
| Mass Range | m/z 10 – 3,000 |
| Resolution | Unit resolution (0.7 Da FWHM) |
| Dynamic Range | >5–6 orders of magnitude |
| Mass Accuracy | High reproducibility for targeted assays |
| Ionization Modes | Jet Stream ESI, APCI, multimode |
| Polarity Switching | <20 ms |
| Acquisition Modes | MRM, dMRM, SIM |
| MRM Transition Speed | >500 transitions/sec |
| Sensitivity (LOQ) | Sub-femtogram level (compound dependent) |
| Collision Cell | LCID with axial acceleration |
| Vacuum System | Turbo molecular pumps |
| Front-End UHPLC | Compatible with Agilent 1200, 1260, and 1290 Infinity UHPLC systems |
| Interface | Orthogonal ESI with iFunnel technology |
| Autosampler | Compatible with Infinity II autosamplers |
| Software | Agilent MassHunter (method development, quantitation, compliance) |
| Compliance | 21 CFR Part 11, GLP/GMP support |