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Agilent 6490 Triple Quadrupole LC/MS  ultra-sensitive quantitative mass spectrometry system with iFunnel technology for pharmaceutical, food safety, environmental, and clinical research applications.

Key Features:

  • Unparalleled Sensitivity: Sub-femtogram detection capability, ideal for low-abundance analytes.

  • Agilent iFunnel Technology: Enhances ion transmission efficiency, boosting signal intensity and sensitivity.

  • Fast Polarity Switching: <20 ms polarity switching for seamless dual-mode analysis.

  • Dynamic MRM (dMRM): Advanced acquisition mode for high-throughput targeted quantitation with improved reproducibility.

  • Ultra-Wide Dynamic Range: >5–6 orders of magnitude, ensuring accurate quantitation from trace to high-level compounds.

  • High MRM Speed: Capable of >500 transitions per second to support UHPLC peak widths.

  • Robust Collision Cell: LCID (linear collision-induced dissociation with axial acceleration) ensures high-quality, reproducible fragmentation.

  • Flexible Ionization: Compatible with Agilent Jet Stream ESI, APCI, and multimode ion sources.

  • Reliability & Uptime: Modular design, straightforward maintenance, and long-lasting performance in demanding labs.

  • Regulatory Compliance: Full 21 CFR Part 11 support with audit trails for GMP/GLP workflows.

  • MassHunter Software Suite: Simplifies data acquisition, quantitation, method optimization, and reporting.


Applications:

  • Pharmaceutical Development: Drug metabolism, pharmacokinetics, toxicology, bioanalysis, and impurity testing.

  • Biopharmaceuticals: Peptide/protein quantitation, stability testing, and process monitoring.

  • Food Safety: Quantitative screening of pesticides, veterinary drugs, mycotoxins, and contaminants.

  • Environmental Analysis: Monitoring trace pollutants, industrial chemicals, and pharmaceuticals in water/soil.

  • Clinical & Forensic Research: Targeted biomarker quantitation, drug testing, forensic toxicology workflows.

  • Metabolomics & Lipidomics: Quantitative profiling of metabolites and lipids.

  • High-Throughput Regulated Labs: Routine, validated workflows with robust performance and audit-ready documentation.


Specifications (Table):

Parameter Specification
System Configuration Agilent 6490 Triple Quadrupole LC/MS
MS Type Triple Quadrupole (LC-MS/MS)
Mass Range m/z 10 – 3,000
Resolution Unit resolution (0.7 Da FWHM)
Dynamic Range >5–6 orders of magnitude
Mass Accuracy High reproducibility for targeted assays
Ionization Modes Jet Stream ESI, APCI, multimode
Polarity Switching <20 ms
Acquisition Modes MRM, dMRM, SIM
MRM Transition Speed >500 transitions/sec
Sensitivity (LOQ) Sub-femtogram level (compound dependent)
Collision Cell LCID with axial acceleration
Vacuum System Turbo molecular pumps
Front-End UHPLC Compatible with Agilent 1200, 1260, and 1290 Infinity UHPLC systems
Interface Orthogonal ESI with iFunnel technology
Autosampler Compatible with Infinity II autosamplers
Software Agilent MassHunter (method development, quantitation, compliance)
Compliance 21 CFR Part 11, GLP/GMP support



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