Skip to product information
Agilent 6495C Triple Quadrupole LC/MS System (G6495CA)  high-sensitivity, robust LC-MS/MS instrument for pharmaceutical, food safety, environmental, clinical, and metabolomics applications.

Key Features:

  • High Sensitivity Performance: Optimized for trace-level detection across complex sample matrices.

  • iFunnel Technology: Maximizes ion transmission and detection efficiency for ultra-low LOQs.

  • Dynamic Range: >6 orders of magnitude for reliable quantitation across diverse concentration levels.

  • Fast Polarity Switching: <20 ms for rapid positive/negative mode analysis within a single injection.

  • Enhanced Collision Cell: LCID (linear collision cell with axial acceleration) for high-quality fragmentation.

  • High Throughput Data Acquisition: Capable of >500 MRM transitions/sec for UHPLC compatibility.

  • Jet Stream ESI Source: Superior desolvation and ion focusing ensure robust signal intensity.

  • MassHunter Software: Comprehensive quantitation tools with regulatory compliance support.

  • Ease of Maintenance: Designed with user-accessible components to minimize downtime.

  • Regulatory Compliance: 21 CFR Part 11 support for secure workflows in regulated laboratories.

  • Trusted Workhorse: Built as a robust, reliable system for demanding routine and research labs.


Applications:

  • Pharmaceutical R&D: PK/TK studies, DMPK, impurity profiling, and clinical bioanalysis.

  • Biopharmaceuticals: Peptide/protein quantitation, process monitoring, and stability assessment.

  • Food Safety: Quantitation of pesticide residues, mycotoxins, veterinary drugs, and food contaminants.

  • Environmental Testing: Emerging pollutants, trace organics, and pharmaceutical residues in soil/water.

  • Clinical & Forensic Toxicology: Screening and quantitation of drugs of abuse, metabolites, and biomarkers.

  • Metabolomics & Lipidomics: Targeted assays for small molecules, lipids, and metabolites in biological research.

  • Routine Regulated Analysis: For GLP/GMP labs requiring validated workflows and reliable performance.


Specifications (Table):

Parameter Specification
System Type Triple Quadrupole LC/MS (LC-MS/MS)
Model 6495C (G6495CA)
Mass Range m/z 10 – 3,000
Resolution Unit mass resolution (0.7 Da FWHM)
Dynamic Range >6 orders of magnitude
Mass Accuracy High reproducibility for quantitative assays
Ionization Modes Agilent Jet Stream ESI, APCI, multimode
Polarity Switching <20 ms
Acquisition Modes MRM, dynamic MRM (dMRM), SIM
MRM Transition Speed >500 transitions/sec
Sensitivity (LOQ) Sub-femtogram (compound dependent)
Collision Cell LCID with axial acceleration
Vacuum System Turbo molecular pumps
Interface Orthogonal ESI with iFunnel technology
Autosampler Compatibility Agilent 1290 Infinity II/III UHPLC autosamplers
Software Agilent MassHunter (method development, quantitation, reporting)
Compliance 21 CFR Part 11 (GLP/GMP labs)



You may also like