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Key Features:
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High Sensitivity Performance: Optimized for trace-level detection across complex sample matrices.
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iFunnel Technology: Maximizes ion transmission and detection efficiency for ultra-low LOQs.
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Dynamic Range: >6 orders of magnitude for reliable quantitation across diverse concentration levels.
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Fast Polarity Switching: <20 ms for rapid positive/negative mode analysis within a single injection.
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Enhanced Collision Cell: LCID (linear collision cell with axial acceleration) for high-quality fragmentation.
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High Throughput Data Acquisition: Capable of >500 MRM transitions/sec for UHPLC compatibility.
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Jet Stream ESI Source: Superior desolvation and ion focusing ensure robust signal intensity.
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MassHunter Software: Comprehensive quantitation tools with regulatory compliance support.
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Ease of Maintenance: Designed with user-accessible components to minimize downtime.
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Regulatory Compliance: 21 CFR Part 11 support for secure workflows in regulated laboratories.
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Trusted Workhorse: Built as a robust, reliable system for demanding routine and research labs.
Applications:
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Pharmaceutical R&D: PK/TK studies, DMPK, impurity profiling, and clinical bioanalysis.
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Biopharmaceuticals: Peptide/protein quantitation, process monitoring, and stability assessment.
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Food Safety: Quantitation of pesticide residues, mycotoxins, veterinary drugs, and food contaminants.
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Environmental Testing: Emerging pollutants, trace organics, and pharmaceutical residues in soil/water.
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Clinical & Forensic Toxicology: Screening and quantitation of drugs of abuse, metabolites, and biomarkers.
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Metabolomics & Lipidomics: Targeted assays for small molecules, lipids, and metabolites in biological research.
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Routine Regulated Analysis: For GLP/GMP labs requiring validated workflows and reliable performance.
Specifications (Table):
| Parameter | Specification |
|---|---|
| System Type | Triple Quadrupole LC/MS (LC-MS/MS) |
| Model | 6495C (G6495CA) |
| Mass Range | m/z 10 – 3,000 |
| Resolution | Unit mass resolution (0.7 Da FWHM) |
| Dynamic Range | >6 orders of magnitude |
| Mass Accuracy | High reproducibility for quantitative assays |
| Ionization Modes | Agilent Jet Stream ESI, APCI, multimode |
| Polarity Switching | <20 ms |
| Acquisition Modes | MRM, dynamic MRM (dMRM), SIM |
| MRM Transition Speed | >500 transitions/sec |
| Sensitivity (LOQ) | Sub-femtogram (compound dependent) |
| Collision Cell | LCID with axial acceleration |
| Vacuum System | Turbo molecular pumps |
| Interface | Orthogonal ESI with iFunnel technology |
| Autosampler Compatibility | Agilent 1290 Infinity II/III UHPLC autosamplers |
| Software | Agilent MassHunter (method development, quantitation, reporting) |
| Compliance | 21 CFR Part 11 (GLP/GMP labs) |