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Key Features:
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Flagship Sensitivity: Delivers industry-leading sensitivity for ultra-trace quantitation of small molecules, peptides, and complex analytes.
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New iFunnel Technology: Enhanced ion transmission for maximum ion capture efficiency and improved limits of detection.
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High Dynamic Range: More than 6 orders of magnitude dynamic range for quantifying analytes across wide concentration levels.
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Fast Polarity Switching: <20 ms enables simultaneous positive/negative mode analysis.
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Robust Quantitative Accuracy: Unit-mass resolution across the mass range with exceptional reproducibility.
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Enhanced Collision Cell: High-efficiency collision cell (LCID) with axial acceleration for rapid, sensitive fragmentation.
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Advanced MRM & dMRM Modes: Supports thousands of transitions with high acquisition speed (>500 transitions/sec).
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Integrated Agilent Jet Stream ESI Source: Maximized desolvation and ion focusing for higher sensitivity.
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System Reliability: Designed for long-term stability, uptime, and reduced maintenance.
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Regulatory-Ready Software: Agilent MassHunter with 21 CFR Part 11 compliance, audit trails, and secure reporting.
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Versatile Workflows: Compatible with UHPLC systems like the Agilent 1290 Infinity II for maximum chromatographic resolution.
Applications:
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Pharmaceutical & Biopharmaceutical: Pharmacokinetics (PK), drug metabolism and pharmacokinetics (DMPK), clinical bioanalysis, impurity profiling, and biotherapeutic quantitation.
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Food Safety & Quality: Pesticide residues, veterinary drugs, mycotoxins, food contaminants, and authenticity testing.
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Environmental Monitoring: Quantitation of emerging contaminants, endocrine disruptors, pharmaceuticals, and personal care products in water, soil, and air.
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Clinical & Forensic Toxicology: Drug testing, biomarker validation, forensic toxicant analysis, and metabolite profiling.
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Proteomics & Metabolomics: Targeted quantitation of proteins, peptides, lipids, and metabolites.
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Regulated Laboratory Workflows: GLP/GMP labs requiring 21 CFR Part 11 compliance and secure validated reporting.
Specifications (Table):
| Parameter | Specification |
|---|---|
| System Type | Triple Quadrupole LC/MS (TQ-MS/MS) |
| Model | 6495D |
| Mass Range | m/z 10 – 3,000 |
| Resolution | Unit mass resolution (0.7 Da FWHM) |
| Mass Accuracy | High reproducibility for quantitative assays |
| Ionization Modes | Agilent Jet Stream ESI, APCI, multimode source |
| Polarity Switching | <20 ms |
| Acquisition Modes | MRM, dynamic MRM (dMRM), SIM |
| Dynamic Range | >6 orders of magnitude |
| MRM Transition Speed | >500 transitions/sec |
| Sensitivity (LOQ) | Sub-femtogram detection limits (compound dependent) |
| Collision Cell | LCID (linear collision cell) with axial acceleration |
| Vacuum System | Dual turbo molecular pumps |
| Interface | Orthogonal ESI with iFunnel technology |
| Autosampler Compatibility | Agilent 1290 Infinity II autosampler or 1260 Infinity II UHPLC |
| Software | Agilent MassHunter (method development, quantitation, compliance-ready) |
| Compliance | 21 CFR Part 11 for GLP/GMP environments |