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Key Features:
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The Agilent 6540 Q-TOF LC/MS with 1260 Infinity II LC delivers high-resolution accurate mass (HRAM) measurements, enabling advanced qualitative and quantitative workflows.
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Provides resolving power >40,000 FWHM with sub-ppm mass accuracy using dual reference mass correction.
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Features wide dynamic range for detecting both trace and high-abundance analytes in complex matrices.
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Integrates seamlessly with the 1260 Infinity II LC, offering reliable, reproducible chromatography with high flexibility.
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Advanced Dual Agilent Jet Stream (AJS) technology improves ionization efficiency for increased sensitivity.
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Flexible acquisition modes, including full-scan MS, MS/MS, and data-independent acquisition (DIA), for targeted and untargeted workflows.
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Supported by Agilent MassHunter software, delivering robust qualitative, quantitative, and compliance-ready analysis.
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Designed for regulated and research environments, compliant with 21 CFR Part 11.
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Applications:
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Proteomics & Metabolomics: In-depth biomarker discovery, pathway analysis, and metabolic profiling.
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Pharmaceutical Development: Drug metabolism, pharmacokinetics (PK), and impurity profiling.
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Food Safety & Quality: Screening for contaminants, residues, and authenticity testing.
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Environmental Testing: Trace analysis of pollutants, pesticides, and emerging contaminants.
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Advanced Research: Structural elucidation of small molecules, peptides, and natural products.
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Specifications:
| Specification | Detail |
|---|---|
| MS Type | Quadrupole Time-of-Flight (Q-TOF) Mass Spectrometer |
| Resolving Power | >40,000 FWHM |
| Mass Range | m/z 20–20,000 |
| Mass Accuracy | ≤ 2 ppm with dual reference mass correction |
| Ionization Modes | ESI, APCI, Dual Agilent Jet Stream (AJS) |
| Dynamic Range | ≥ 5 orders of magnitude |
| Acquisition Modes | Full scan MS, MS/MS, Data-independent acquisition (DIA) |
| Scan Speed | Up to 50 spectra/sec |
| Vacuum System | High-efficiency turbomolecular pump |
| Interface | Orthogonal spray with advanced ion optics |
| LC System | Agilent 1260 Infinity II LC |
| Software | Agilent MassHunter Suite (Qualitative & Quantitative) |
| Compliance | 21 CFR Part 11, GLP, GMP |