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Agilent 6540 Q-TOF LC/MS with 1260 Infinity II LC  high-resolution accurate-mass LC-MS system for proteomics, pharmaceutical research, metabolomics, and food and environmental testing
  • Key Features:

    • The Agilent 6540 Q-TOF LC/MS with 1260 Infinity II LC delivers high-resolution accurate mass (HRAM) measurements, enabling advanced qualitative and quantitative workflows.

    • Provides resolving power >40,000 FWHM with sub-ppm mass accuracy using dual reference mass correction.

    • Features wide dynamic range for detecting both trace and high-abundance analytes in complex matrices.

    • Integrates seamlessly with the 1260 Infinity II LC, offering reliable, reproducible chromatography with high flexibility.

    • Advanced Dual Agilent Jet Stream (AJS) technology improves ionization efficiency for increased sensitivity.

    • Flexible acquisition modes, including full-scan MS, MS/MS, and data-independent acquisition (DIA), for targeted and untargeted workflows.

    • Supported by Agilent MassHunter software, delivering robust qualitative, quantitative, and compliance-ready analysis.

    • Designed for regulated and research environments, compliant with 21 CFR Part 11.

  • Applications:

    • Proteomics & Metabolomics: In-depth biomarker discovery, pathway analysis, and metabolic profiling.

    • Pharmaceutical Development: Drug metabolism, pharmacokinetics (PK), and impurity profiling.

    • Food Safety & Quality: Screening for contaminants, residues, and authenticity testing.

    • Environmental Testing: Trace analysis of pollutants, pesticides, and emerging contaminants.

    • Advanced Research: Structural elucidation of small molecules, peptides, and natural products.

  • Specifications:

Specification Detail
MS Type Quadrupole Time-of-Flight (Q-TOF) Mass Spectrometer
Resolving Power >40,000 FWHM
Mass Range m/z 20–20,000
Mass Accuracy ≤ 2 ppm with dual reference mass correction
Ionization Modes ESI, APCI, Dual Agilent Jet Stream (AJS)
Dynamic Range ≥ 5 orders of magnitude
Acquisition Modes Full scan MS, MS/MS, Data-independent acquisition (DIA)
Scan Speed Up to 50 spectra/sec
Vacuum System High-efficiency turbomolecular pump
Interface Orthogonal spray with advanced ion optics
LC System Agilent 1260 Infinity II LC
Software Agilent MassHunter Suite (Qualitative & Quantitative)
Compliance 21 CFR Part 11, GLP, GMP

 

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