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Agilent 6540 Q-TOF LC/MS  advanced high-resolution accurate-mass quadrupole time-of-flight LC-MS system for proteomics, pharmaceutical R&D, metabolomics, and food and environmental testing
  • Key Features:

    • The Agilent 6540 Q-TOF LC/MS provides high-resolution accurate mass (HRAM) performance, ideal for advanced qualitative and quantitative analysis.

    • Achieves >40,000 FWHM resolution with dual reference mass correction for sub-ppm mass accuracy.

    • Incorporates Agilent Jet Stream (AJS) technology for enhanced ionization efficiency and improved sensitivity.

    • Offers fast acquisition speeds (up to 50 spectra/sec) to handle complex LC peaks without loss of data quality.

    • Supports full MS, MS/MS, and data-independent acquisition (DIA) workflows for both discovery and targeted studies.

    • Capable of handling a wide dynamic range, enabling trace-level detection alongside high-abundance compounds.

    • Fully compatible with Agilent LC systems and MassHunter software for data processing, compliance, and reporting.

    • Designed for regulated environments with 21 CFR Part 11 compliance.

  • Applications:

    • Proteomics & Metabolomics: Biomarker discovery, metabolic profiling, pathway analysis.

    • Pharmaceutical Research: Drug discovery, impurity analysis, ADME studies.

    • Food Safety & Quality: Screening for contaminants, authenticity testing, residue monitoring.

    • Environmental Testing: Detection of pollutants, pesticides, and trace contaminants.

    • Advanced Chemical Research: Structure elucidation of small molecules, peptides, and natural products.

  • Specifications:

Specification Detail
MS Type Quadrupole Time-of-Flight (Q-TOF) Mass Spectrometer
Resolving Power >40,000 FWHM
Mass Range m/z 20–20,000
Mass Accuracy ≤ 2 ppm with dual reference mass correction
Ionization Modes ESI, APCI, Dual Agilent Jet Stream (AJS)
Dynamic Range ≥ 5 orders of magnitude
Acquisition Modes Full scan MS, MS/MS, Data-independent acquisition (DIA)
Scan Speed Up to 50 spectra/sec
Vacuum System High-efficiency turbomolecular pump
Interface Orthogonal spray with optimized ion optics
Software Agilent MassHunter Suite (Qualitative & Quantitative)
Compliance 21 CFR Part 11, GLP, GMP

 

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