Key Features:

• AdvanceBio LC/Q-TOF Platform: Optimized for biopharmaceutical characterization, including intact proteins, oligonucleotides, glycans, and complex biologics.

• High-Resolution Accurate Mass (HRAM): Resolving power >40,000 FWHM with sub-1 ppm mass accuracy using reference mass correction.

• Bio-Inert UHPLC Integration: 1290 Infinity II Bio-Inert LC system ensures minimal sample interaction and superior chromatographic separation for sensitive biomolecules.

• Extended Mass Range: Broad m/z coverage suitable for peptides, intact proteins, and large biomolecules.

• Native MS Capability: Preserves non-covalent interactions and higher-order protein structures during analysis.

• Robust Sensitivity & Dynamic Range: Detects trace impurities and post-translational modifications (PTMs) in complex samples.

• Flexible Ionization Sources: Supports ESI (positive/negative), Jet Stream technology for enhanced ionization, APCI, and multimode ion sources.

• Comprehensive Acquisition Modes: Full-scan, AutoMS/MS, targeted MS/MS, DIA, DDA.

• Polarity Switching: Fast switching (<20 ms) for expanded compound coverage.

• Data Visualization & Interpretation: CCS (collision cross section) measurements with accurate annotation of biomolecules.

• Advanced Software Ecosystem: Agilent MassHunter with BioConfirm workflows for intact protein and glycan analysis.

• Regulatory Ready: 21 CFR Part 11 compliance for biopharma, GLP/GMP environments.

• Automation & Scalability: Seamless integration with autosamplers and high-throughput workflows.

Applications:

• Biopharmaceutical Analysis: Intact mass analysis, biosimilar comparability, monoclonal antibody (mAb) characterization.

• Proteomics: PTM identification, protein sequencing, biomarker discovery.

• Glycomics & Glycoproteomics: Characterization of N-linked and O-linked glycans.

• Oligonucleotide Analysis: Quality control and characterization of therapeutic oligonucleotides.

• Native Mass Spectrometry: Structural biology studies with preserved protein complexes.

• Pharmaceutical Development: Drug metabolism studies, impurity profiling, metabolite identification.

• Food & Environmental Testing: Analysis of complex biological matrices for contaminants and trace-level analytes.

• Forensics & Clinical Research: Advanced biomarker screening and toxicology studies.

Specifications (Table):