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Key Features:
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The Agilent 6546 LC/Q-TOF is a high-resolution accurate-mass Q-TOF LC/MS system engineered for proteomics, metabolomics, pharmaceutical development, and advanced research workflows.
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Delivers resolution >60,000 FWHM with sub-1 ppm mass accuracy, enabling confident compound identification in complex samples.
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Incorporates Agilent Jet Stream Technology and dual-ion funnel optics for enhanced sensitivity and stable ion transmission.
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Capable of fast scan speeds up to 50 spectra/sec, ensuring compatibility with ultra-fast UHPLC separations.
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Offers broad mass range coverage (m/z 20–20,000) for both small molecules and intact biomolecules.
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Features Data-Independent Acquisition (DIA), MS/MS, and targeted quantitation modes for discovery and quantitative applications.
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Integrated with Agilent MassHunter software suite for qualitative, quantitative, and compliance-ready workflows (21 CFR Part 11).
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Designed for robust performance, reproducibility, and high-throughput laboratories.
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Applications:
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Proteomics: Protein identification, PTM characterization, biomarker discovery.
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Metabolomics & Lipidomics: Metabolite profiling, biomarker analysis, systems biology.
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Pharmaceutical & Biopharma: Drug development, impurity profiling, intact mass analysis.
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Food Safety & Quality: Detection of contaminants, authenticity testing.
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Environmental Research: Screening and quantitation of emerging pollutants.
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Specifications:
| Specification | Detail |
|---|---|
| MS Type | Quadrupole Time-of-Flight (Q-TOF) LC/MS |
| Resolution | >60,000 FWHM |
| Mass Accuracy | ≤1 ppm with dual-reference correction |
| Mass Range | m/z 20–20,000 |
| Ionization Sources | ESI, APCI, Dual AJS (Agilent Jet Stream) |
| Dynamic Range | ≥ 5 orders of magnitude |
| Acquisition Modes | Full scan, MS/MS, DIA, targeted quantitation |
| Scan Speed | Up to 50 spectra/sec |
| Software | Agilent MassHunter (Qualitative, Quantitative, Compliance-ready) |
| Compliance | 21 CFR Part 11, GMP, GLP |