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Agilent 6546 LC/Q-TOF Quadrupole Time-of-Flight LC/MS high-resolution accurate-mass Q-TOF system with >60,000 FWHM resolution, Jet Stream ionization, and advanced DIA workflows for proteomics, metabolomics, pharmaceuticals, food safety, and environmental research.
  • Key Features:

    • The Agilent 6546 LC/Q-TOF is a high-resolution accurate-mass Q-TOF LC/MS system engineered for proteomics, metabolomics, pharmaceutical development, and advanced research workflows.

    • Delivers resolution >60,000 FWHM with sub-1 ppm mass accuracy, enabling confident compound identification in complex samples.

    • Incorporates Agilent Jet Stream Technology and dual-ion funnel optics for enhanced sensitivity and stable ion transmission.

    • Capable of fast scan speeds up to 50 spectra/sec, ensuring compatibility with ultra-fast UHPLC separations.

    • Offers broad mass range coverage (m/z 20–20,000) for both small molecules and intact biomolecules.

    • Features Data-Independent Acquisition (DIA), MS/MS, and targeted quantitation modes for discovery and quantitative applications.

    • Integrated with Agilent MassHunter software suite for qualitative, quantitative, and compliance-ready workflows (21 CFR Part 11).

    • Designed for robust performance, reproducibility, and high-throughput laboratories.

  • Applications:

    • Proteomics: Protein identification, PTM characterization, biomarker discovery.

    • Metabolomics & Lipidomics: Metabolite profiling, biomarker analysis, systems biology.

    • Pharmaceutical & Biopharma: Drug development, impurity profiling, intact mass analysis.

    • Food Safety & Quality: Detection of contaminants, authenticity testing.

    • Environmental Research: Screening and quantitation of emerging pollutants.

  • Specifications:

Specification Detail
MS Type Quadrupole Time-of-Flight (Q-TOF) LC/MS
Resolution >60,000 FWHM
Mass Accuracy ≤1 ppm with dual-reference correction
Mass Range m/z 20–20,000
Ionization Sources ESI, APCI, Dual AJS (Agilent Jet Stream)
Dynamic Range ≥ 5 orders of magnitude
Acquisition Modes Full scan, MS/MS, DIA, targeted quantitation
Scan Speed Up to 50 spectra/sec
Software Agilent MassHunter (Qualitative, Quantitative, Compliance-ready)
Compliance 21 CFR Part 11, GMP, GLP



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