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Key Features:
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The Agilent 6560 Ion Mobility Q-TOF LC/MS combines high-resolution Q-TOF mass spectrometry with drift tube ion mobility separation (DTIMS) for an additional dimension of molecular characterization.
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Provides >60,000 FWHM resolution and sub-ppm mass accuracy, ensuring precise identification and confident compound annotation.
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The ion mobility separation enables differentiation of isomers and conformers, delivering enhanced selectivity in complex sample analysis.
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Equipped with Agilent Jet Stream ionization and iFunnel technology, improving sensitivity and transmission efficiency.
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Broad mass range up to m/z 20,000, supporting small molecule, peptide, and intact biomolecule analysis.
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Acquisition speeds up to 50 spectra/sec, compatible with fast UHPLC workflows.
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Advanced collision cross section (CCS) measurements add structural information to traditional mass/charge data.
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Controlled by Agilent MassHunter software, supporting qualitative, quantitative, and compliance-ready workflows (21 CFR Part 11).
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Applications:
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Proteomics & Structural Biology: Protein conformational studies, PTM analysis, biomarker research.
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Metabolomics & Lipidomics: Resolving isomers, biomarker discovery, complex profiling.
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Pharmaceutical Research: Structural characterization, impurity analysis, drug discovery.
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Biopharmaceutical Development: Intact protein and glycan analysis, therapeutic characterization.
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Environmental & Food Safety: Identifying isomeric pollutants, food authenticity testing.
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Specifications:
| Specification | Detail |
|---|---|
| MS Type | Ion Mobility Quadrupole Time-of-Flight (Q-TOF) LC/MS |
| Ion Mobility | Drift Tube Ion Mobility Separation (DTIMS) |
| Resolution | >60,000 FWHM |
| Mass Accuracy | ≤1 ppm with dual-reference correction |
| Mass Range | m/z 20–20,000 |
| Ionization Sources | ESI, APCI, Dual AJS (Agilent Jet Stream) with iFunnel |
| Dynamic Range | ≥ 5 orders of magnitude |
| Acquisition Modes | Full scan, MS/MS, DIA, targeted workflows |
| Scan Speed | Up to 50 spectra/sec |
| Software | Agilent MassHunter (Qualitative, Quantitative, CCS-enabled) |
| Compliance | 21 CFR Part 11, GMP, GLP |