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Agilent 6560 Ion Mobility Q-TOF LC/MS advanced high-resolution UHPLC-MS system with drift tube ion mobility separation, accurate-mass Q-TOF performance, and structural CCS measurements for proteomics, metabolomics, pharmaceuticals, and biopharmaceutical research.
  • Key Features:

    • The Agilent 6560 Ion Mobility Q-TOF LC/MS combines high-resolution Q-TOF mass spectrometry with drift tube ion mobility separation (DTIMS) for an additional dimension of molecular characterization.

    • Provides >60,000 FWHM resolution and sub-ppm mass accuracy, ensuring precise identification and confident compound annotation.

    • The ion mobility separation enables differentiation of isomers and conformers, delivering enhanced selectivity in complex sample analysis.

    • Equipped with Agilent Jet Stream ionization and iFunnel technology, improving sensitivity and transmission efficiency.

    • Broad mass range up to m/z 20,000, supporting small molecule, peptide, and intact biomolecule analysis.

    • Acquisition speeds up to 50 spectra/sec, compatible with fast UHPLC workflows.

    • Advanced collision cross section (CCS) measurements add structural information to traditional mass/charge data.

    • Controlled by Agilent MassHunter software, supporting qualitative, quantitative, and compliance-ready workflows (21 CFR Part 11).

  • Applications:

    • Proteomics & Structural Biology: Protein conformational studies, PTM analysis, biomarker research.

    • Metabolomics & Lipidomics: Resolving isomers, biomarker discovery, complex profiling.

    • Pharmaceutical Research: Structural characterization, impurity analysis, drug discovery.

    • Biopharmaceutical Development: Intact protein and glycan analysis, therapeutic characterization.

    • Environmental & Food Safety: Identifying isomeric pollutants, food authenticity testing.

  • Specifications:

Specification Detail
MS Type Ion Mobility Quadrupole Time-of-Flight (Q-TOF) LC/MS
Ion Mobility Drift Tube Ion Mobility Separation (DTIMS)
Resolution >60,000 FWHM
Mass Accuracy ≤1 ppm with dual-reference correction
Mass Range m/z 20–20,000
Ionization Sources ESI, APCI, Dual AJS (Agilent Jet Stream) with iFunnel
Dynamic Range ≥ 5 orders of magnitude
Acquisition Modes Full scan, MS/MS, DIA, targeted workflows
Scan Speed Up to 50 spectra/sec
Software Agilent MassHunter (Qualitative, Quantitative, CCS-enabled)
Compliance 21 CFR Part 11, GMP, GLP

 

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